吡哆胺作为血浆苄胺氧化酶和其他含铜胺氧化酶的抑制剂。
Pyridoxamine as inhibitor of the blood plasma benzylamine oxidase and other copper-containing amine oxidases.
作者信息
Buffoni F, Banchelli G, Dolara P, Ignesti G, Pirisino R, Raimondi L, Ziche M
出版信息
J Pharm Pharmacol. 1985 Aug;37(8):597-600. doi: 10.1111/j.2042-7158.1985.tb03080.x.
Abstract
Pyridoxamine inhibits rabbit and pig plasma benzylamine oxidase (BAO), the diamine oxidase of pig kidney and the lysyloxidase of pig aorta in-vitro. In-vivo in the rabbit, the inhibitory activity of pyridoxamine on plasma BAO is antagonized by an increase in the level of this enzyme that is dependent on an increase in rate of synthesis, there being no variation in the degradation rate constant.
摘要
吡哆胺在体外可抑制兔和猪血浆中的苄胺氧化酶（BAO）、猪肾中的二胺氧化酶以及猪主动脉中的赖氨酰氧化酶。在兔体内，吡哆胺对血浆BAO的抑制活性会被该酶水平的升高所拮抗，这种升高依赖于合成速率的增加，而降解速率常数并无变化。
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