猪血浆苄胺氧化酶与β-氨基丙腈的反应
Reaction of pig plasma benzylamine oxidase with beta-aminopropionitrile.
作者信息
Raimondi L, Banchelli G, Bertocci B, Lodovici M, Ignesti G, Pirisino R, Buffoni F, Bertini V, De Munno A
出版信息
Agents Actions. 1985 Apr;16(3-4):95-8. doi: 10.1007/BF01983110.
PMID:4013920
Abstract
Beta-aminopropionitrile (BAPN) is an inhibitor of pig plasma benzylamine oxidase. BAPN is oxidized by benzylamine oxidase. Inhibition develops in a time-dependent fashion upon incubation of BAPN with the enzyme in the absence of substrate. The product of oxidation of BAPN by benzylamine oxidase, cyanacetaldehyde, was identified and prepared by synthesis. It is an irreversible inhibitor of the enzyme.
摘要
β-氨基丙腈（BAPN）是猪血浆苄胺氧化酶的一种抑制剂。BAPN可被苄胺氧化酶氧化。在无底物的情况下，将BAPN与该酶一起孵育时，抑制作用会随时间推移而产生。已鉴定出并通过合成制备了苄胺氧化酶氧化BAPN的产物氰基乙醛。它是该酶的一种不可逆抑制剂。
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