Otsuka T, Okamura S, Niho Y, Kusaba T
J Rheumatol. 1985 Jun;12(3):508-13.
We have examined the ability of B cells from patients with systemic lupus erythematosus (SLE) to form colonies in vitro. Significantly more B cell colonies growing in the absence of irradiated T cells were observed in patients with active SLE. Helper T cell function of active SLE was normal. Culture supernatants of SLE T cells had significantly less activity to support the B cell colony formation. Our results suggest that the hyperactivity of B cells in SLE may reside in the lupus B cells themselves and that SLE T cells are defective in releasing the soluble factor.
我们检测了系统性红斑狼疮（SLE）患者的B细胞在体外形成集落的能力。在活动性SLE患者中，观察到在无辐照T细胞情况下生长的B细胞集落明显更多。活动性SLE患者的辅助性T细胞功能正常。SLE T细胞的培养上清液支持B细胞集落形成的活性明显较低。我们的结果表明，SLE中B细胞的活性过高可能存在于狼疮B细胞自身，且SLE T细胞在释放可溶性因子方面存在缺陷。
