Wang Bi, Zhao Liang, Zhu Weiwei, Fang Liming, Ren Fuzeng
Department of Materials Science and Engineering, South University of Science and Technology of China, Shenzhen, Guangdong 518055, China.
Department of Polymer Science and Engineering, School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.
Colloids Surf B Biointerfaces. 2017 Sep 1;157:432-439. doi: 10.1016/j.colsurfb.2017.06.013. Epub 2017 Jun 17.
Magnesium alloys are promising candidates for load-bearing orthopedic implants due to their biodegradability and mechanical resemblance to natural bone tissue. However, the high degradation rate and the risk of implant-associated infections pose grand challenges for their clinical applications. Herein, we developed a nano-multilayered coating strategy through polydopamine and chitosan assisted layer-by-layer assembly of osteoinductive carbonated apatite and antibacterial sliver nanoparticles on the surface of AZ31 magnesium alloys. The fabricated nano-multilayered coating can not only obviously enhance the corrosion resistance but also significantly increase the antibacterial activity and demonstrate better biocompatility of magnesium alloys.
镁合金因其生物可降解性以及与天然骨组织的力学相似性，是用于承重骨科植入物的有前景的候选材料。然而，高降解速率和植入物相关感染的风险给它们的临床应用带来了巨大挑战。在此，我们通过聚多巴胺和壳聚糖辅助的层层组装，在AZ31镁合金表面制备了具有骨诱导性的碳酸磷灰石和抗菌银纳米颗粒的纳米多层涂层策略。所制备的纳米多层涂层不仅能显著提高耐腐蚀性，还能显著增强抗菌活性，并展现出镁合金更好的生物相容性。
