College of Materials Science and Engineering, Shandong University of Science and Technology, Qingdao, 266590, China.
Department of Oral and Maxillofacial Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, 266000, China; Key Lab of Oral Clinical Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, 266000, China.
Colloids Surf B Biointerfaces. 2019 Jul 1;179:429-436. doi: 10.1016/j.colsurfb.2019.04.029. Epub 2019 Apr 13.
As a result of their good biocompatibility, bioactivity, and mechanical properties, magnesium (Mg) alloys have received considerable attention as next generation biodegradable implants. Herein, in order to achieve a proper degradation rate and good antibacterial ability, we reported a novel hydroxyapatite coating induced by gentamicin (GS)-loaded polymeric multilayers for the surface treatment of the Mg alloy. The coating was characterized by X-ray diffraction, fourier transform infrared spectroscopy and scanning electron microscopy. The as-prepared hydroxyapatite coating showed the compact morphology and a well-crystallized apatite structure. This coating could improve the adhesion strength and reduce the corrosion rate of the substrate in simulated body fluid solution. Meanwhile, the drug release and antibacterial experiments demonstrated that the GS loaded specimen revealed a significant antimicrobial performance toward Staphylococcus aureus and had a prolonged release profile of GS, which would be helpful to the long-term bactericidal activity of the Mg implant. This coating showed acceptable biocompatibility via MTT assay and Live/dead staining. Thus, the multilayers-hydroxyapatite coated Mg alloy could improve the corrosion resistance and biocompatibility while delivering vital drugs to the site of implantation.
由于其良好的生物相容性、生物活性和机械性能，镁（Mg）合金作为下一代可生物降解植入物受到了广泛关注。在此，为了达到适当的降解速率和良好的抗菌能力，我们报道了一种新型的庆大霉素（GS）负载聚合物多层诱导的羟基磷灰石涂层，用于镁合金的表面处理。通过 X 射线衍射、傅里叶变换红外光谱和扫描电子显微镜对涂层进行了表征。所制备的羟基磷灰石涂层具有致密的形态和良好结晶的磷灰石结构。这种涂层可以提高在模拟体液溶液中基底的附着强度和降低腐蚀速率。同时，药物释放和抗菌实验表明，负载 GS 的样品对金黄色葡萄球菌表现出显著的抗菌性能，并具有 GS 的延长释放曲线，这有助于镁植入物的长期杀菌活性。通过 MTT 测定和 Live/Dead 染色，该涂层显示出良好的生物相容性。因此，多层-羟基磷灰石涂层镁合金可以提高耐腐蚀性和生物相容性，同时向植入部位输送重要药物。
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