1 School of Public Health, The University of Texas Health Science Center at Houston, Houston, USA.
2 McGovern Medical School, The University of Texas Health Science Center at Houston, Housten, USA.
J Appl Gerontol. 2019 Jun;38(6):866-883. doi: 10.1177/0733464817714565. Epub 2017 Jun 23.
Determine whether medication regimen complexity predicts medication adherence levels in a sample of community-dwelling adults 65 years and older with Adult Protective Services-substantiated self-neglect.
A cross-sectional analysis of baseline data ( N = 31 participants) from a pilot intervention to increase medication adherence among the target group was performed. The Medication Regimen Complexity Index (MRCI) and the 8-item Morisky Medication Adherence Scale (MMAS-8)™ were the primary independent and dependent measures, respectively. A multivariable linear regression analysis, adjusting for potential confounders, was conducted to estimate the association between complexity and adherence.
Regimen complexity was high (mean MRCI = 19.6) and adherence was low (mean MMAS = 5.1). Even after controlling for confounders, increased complexity was significantly associated with lower adherence.
Older community-dwelling adults who self-neglect have complex medication regimens that contribute to low medication adherence. Medication regimen complexity may be a modifiable contributor to low adherence that can be targeted by future interventions to reduce self-neglect and its consequences.
在一个有成人保护服务机构证实的自我忽视的 65 岁及以上的社区居住的成年人样本中，确定药物治疗方案的复杂性是否可以预测药物依从性水平。
对一项旨在提高目标人群药物依从性的试点干预措施的基线数据（N=31 名参与者）进行了横断面分析。药物治疗方案复杂性指数（MRCI）和 8 项 Morisky 药物依从性量表（MMAS-8）™分别是主要的独立和依赖测量指标。进行了多变量线性回归分析，以调整潜在的混杂因素，估计复杂性与依从性之间的关联。
治疗方案的复杂性很高（平均 MRCI=19.6），而依从性很低（平均 MMAS=5.1）。即使在控制了混杂因素后，复杂性的增加与较低的依从性显著相关。
自我忽视的老年社区居住成年人有复杂的药物治疗方案，导致药物依从性低。药物治疗方案的复杂性可能是导致低依从性的一个可改变的因素，可以通过未来的干预措施来减少自我忽视及其后果。
