硫唑嘌呤和环孢素：需要不同的组织匹配标准吗？
Azathioprine and cyclosporin: different tissue matching criteria needed?
作者信息
Harris K R, Digard N, Gosling D C, Tate D G, Campbell M J, Gardner B, Sharman V L, Slapak M
出版信息
Lancet. 1985 Oct 12;2(8459):802-5. doi: 10.1016/s0140-6736(85)90795-0.
PMID:2864533
Abstract
Of 275 renal transplants performed over seven years in a single unit, azathioprine was the main immunosuppressive agent in 128 and cyclosporin in 147. With azathioprine graft survival was, as expected, negatively related to the number of HLA mismatches; with cyclosporin the reverse held true.
摘要
在一个单位七年内进行的275例肾移植中，128例以硫唑嘌呤作为主要免疫抑制剂，147例以环孢素作为主要免疫抑制剂。使用硫唑嘌呤时，移植物存活率与HLA错配数呈负相关，这正如预期；而使用环孢素时情况则相反。
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