CNRS, Institut de Biochimie et de Génétique Cellulaires, UMR5095, 1 Rue Camille Saint-Saëns, 33077 Bordeaux, France; Université de Bordeaux, Institut de Biochimie et de Génétique Cellulaires, UMR5095, 1 Rue Camille Saint-Saëns, 33077 Bordeaux, France.
CNRS, Institut de Biochimie et de Génétique Cellulaires, UMR5095, 1 Rue Camille Saint-Saëns, 33077 Bordeaux, France; Université de Bordeaux, Institut de Biochimie et de Génétique Cellulaires, UMR5095, 1 Rue Camille Saint-Saëns, 33077 Bordeaux, France; EA 3842, Homéostasie Cellulaire et Pathologies, Université de Limoges, 2, rue du Docteur Marcland, 87025 Limoges Cedex, France.
Biochim Biophys Acta Mol Cell Res. 2017 Oct;1864(10):1734-1745. doi: 10.1016/j.bbamcr.2017.06.012. Epub 2017 Jun 21.
Bcl-2 family proteins control programmed cell death through a complex network of interactions within and outside of this family, that are modulated by post-translational modifications (PTM). Bcl-x, an anti-apoptotic member of this family, is overexpressed in a number of cancers, plays an important role in tumorigenesis and is correlated with drug resistance. Bcl-x is susceptible to a number of different PTMs. Here, we focus on deamidation. We will first provide an overview of protein deamidation. We will then review how the apoptotic and autophagic functions of Bcl-x are modified by this PTM, and how this impacts on its oncogenic properties. Possible therapeutic outcomes will also be discussed. Finally, we will highlight how the specific case of Bcl-x deamidation provides groundings to revisit some concepts related to protein deamidation in general.
Bcl-2 家族蛋白通过家族内外的复杂相互作用网络来控制程序性细胞死亡，这些相互作用受到翻译后修饰（PTM）的调节。Bcl-x 是该家族的一种抗凋亡成员，在许多癌症中过度表达，在肿瘤发生中发挥重要作用，并与耐药性相关。Bcl-x 易受到多种不同的 PTM 的影响。在这里，我们专注于脱酰胺作用。我们将首先提供蛋白质脱酰胺作用的概述。然后，我们将回顾这种 PTM 如何改变 Bcl-x 的凋亡和自噬功能，以及这如何影响其致癌特性。还将讨论可能的治疗结果。最后，我们将强调 Bcl-x 脱酰胺作用的具体情况如何为重新审视与一般蛋白质脱酰胺作用相关的一些概念提供基础。
