Biotech Research & Innovation Centre (BRIC), Department of Health and Medical Sciences, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen N, Denmark.
Biotech Research & Innovation Centre (BRIC), Department of Health and Medical Sciences, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen N, Denmark.
Biochim Biophys Acta Mol Basis Dis. 2018 Apr;1864(4 Pt B):1423-1434. doi: 10.1016/j.bbadis.2017.06.014. Epub 2017 Jun 20.
Epigenomics is a fast-evolving field of research that has lately attracted considerable interest, mainly due to the reversibility of epigenetic marks. Clinically, among solid tumors, the field is still limited. In cholangiocarcinoma (CCA) it is well known that the epigenetic landscape is deregulated both during carcinogenesis and disease progression as a consequence of aberrant mechanisms leading to genome instability. In this article, we will briefly review the molecular alterations that have been described in the transformation of normal cholangiocytes into malignant derivatives, focusing on the role of non-coding RNA (ncRNA) interactions, DNA methylation, post-translational modifications (PTMs) of histones and chromatin remodeling complexes.
表观基因组学是一个快速发展的研究领域，最近引起了相当大的关注，主要是因为表观遗传标记具有可逆性。在临床上，在实体肿瘤中，该领域仍然有限。在胆管癌（CCA）中，众所周知，由于导致基因组不稳定的异常机制，表观遗传景观在癌变和疾病进展过程中都受到了调节。在本文中，我们将简要回顾一下在正常胆管细胞向恶性衍生转化过程中描述的分子改变，重点介绍非编码 RNA（ncRNA）相互作用、DNA 甲基化、组蛋白翻译后修饰（PTMs）和染色质重塑复合物的作用。
