在嵌合抗原受体T细胞扩增过程中，低白细胞介素-2浓度有利于早期记忆性T细胞而非效应细胞表型的产生。 - Suppr

Low interleukin-2 concentration favors generation of early memory T cells over effector phenotypes during chimeric antigen receptor T-cell expansion.

作者信息

Kaartinen Tanja, Luostarinen Annu, Maliniemi Pilvi, Keto Joni, Arvas Mikko, Belt Heini, Koponen Jonna, Mäkinen Petri I, Loskog Angelica, Mustjoki Satu, Porkka Kimmo, Ylä-Herttuala Seppo, Korhonen Matti

机构信息

Advanced Cell Therapy Centre, Finnish Red Cross Blood Service, Helsinki, Finland.

Advanced Cell Therapy Centre, Finnish Red Cross Blood Service, Helsinki, Finland; Research & Development, Finnish Red Cross Blood Service, Helsinki, Finland.

出版信息

Cytotherapy. 2017 Sep;19(9):1130. doi: 10.1016/j.jcyt.2017.06.003. Epub 2017 Jun 20.

DOI:10.1016/j.jcyt.2017.06.003

PMID:28645733

Abstract

摘要

相似文献

Low interleukin-2 concentration favors generation of early memory T cells over effector phenotypes during chimeric antigen receptor T-cell expansion.在嵌合抗原受体T细胞扩增过程中，低白细胞介素-2浓度有利于早期记忆性T细胞而非效应细胞表型的产生。

Cytotherapy. 2017 Sep;19(9):1130. doi: 10.1016/j.jcyt.2017.06.003. Epub 2017 Jun 20.

Cytotherapy. 2017 Jun;19(6):689-702. doi: 10.1016/j.jcyt.2017.03.067. Epub 2017 Apr 11.

Different cytokine and stimulation conditions influence the expansion and immune phenotype of third-generation chimeric antigen receptor T cells specific for tumor antigen GD2.不同的细胞因子和刺激条件会影响针对肿瘤抗原GD2的第三代嵌合抗原受体T细胞的扩增和免疫表型。

Cytotherapy. 2015 Apr;17(4):487-95. doi: 10.1016/j.jcyt.2014.12.002. Epub 2015 Jan 6.

Ex vivo culture of chimeric antigen receptor T cells generates functional CD8+ T cells with effector and central memory-like phenotype.嵌合抗原受体 T 细胞的体外培养产生具有效应和中央记忆样表型的功能性 CD8+T 细胞。

Gene Ther. 2010 Sep;17(9):1105-16. doi: 10.1038/gt.2010.59. Epub 2010 Apr 29.

Optimization of Human NK Cell Manufacturing: Fully Automated Separation, Improved Ex Vivo Expansion Using IL-21 with Autologous Feeder Cells, and Generation of Anti-CD123-CAR-Expressing Effector Cells.人自然杀伤细胞制备的优化：全自动分离，使用 IL-21 和自体饲养细胞进行体外扩增的改进，以及生成表达抗 CD123-CAR 的效应细胞。

Hum Gene Ther. 2017 Oct;28(10):897-913. doi: 10.1089/hum.2017.157. Epub 2017 Aug 15.

Mesothelin-targeting chimeric antigen receptor-modified T cells by piggyBac transposon system suppress the growth of bile duct carcinoma.通过猪尾巴转座子系统靶向间皮素的嵌合抗原受体修饰的T细胞抑制胆管癌的生长。

Tumour Biol. 2017 Apr;39(4):1010428317695949. doi: 10.1177/1010428317695949.

Early effector cells survive the contraction phase in malaria infection and generate both central and effector memory T cells.早期效应细胞在疟疾感染的收缩期存活下来，并产生中枢记忆T细胞和效应记忆T细胞。

J Immunol. 2015 Jun 1;194(11):5346-54. doi: 10.4049/jimmunol.1403216. Epub 2015 Apr 24.

Interleukin-15 favors the expansion of central memory CD8+ T cells in ex vivo generated, antileukemia human cytotoxic T lymphocyte lines.白细胞介素-15有利于体外生成的抗白血病人细胞毒性T淋巴细胞系中中枢记忆性CD8 + T细胞的扩增。

J Immunother. 2008 May;31(4):385-93. doi: 10.1097/CJI.0b013e31816b1092.

Signals required for programming effector and memory development by CD8+ T cells.CD8+ T细胞编程效应器和记忆细胞发育所需的信号。

Immunol Rev. 2006 Jun;211:81-92. doi: 10.1111/j.0105-2896.2006.00382.x.

Interleukin 15 promotes antigen-independent in vitro expansion and long-term survival of antitumor cytotoxic T lymphocytes.白细胞介素15可促进抗肿瘤细胞毒性T淋巴细胞在体外进行不依赖抗原的扩增及长期存活。

Clin Cancer Res. 2002 Dec;8(12):3877-84.

引用本文的文献

Using the Jurkat reporter T cell line for evaluating the functionality of novel chimeric antigen receptors.使用Jurkat报告T细胞系评估新型嵌合抗原受体的功能。

Front Mol Med. 2023 Feb 22;3:1070384. doi: 10.3389/fmmed.2023.1070384. eCollection 2023.

Increasing Gene Editing Efficiency via CRISPR/Cas9- or Cas12a-Mediated Knock-In in Primary Human T Cells.通过CRISPR/Cas9或Cas12a介导的原代人T细胞敲入提高基因编辑效率

Biomedicines. 2024 Jan 6;12(1):119. doi: 10.3390/biomedicines12010119.

X-ray-irradiated K562 feeder cells for expansion of functional CAR-T cells.用于功能性嵌合抗原受体T细胞（CAR-T细胞）扩增的经X射线照射的K562饲养细胞

Biochem Biophys Rep. 2022 Dec 1;33:101399. doi: 10.1016/j.bbrep.2022.101399. eCollection 2023 Mar.

Combined analysis of T cell activation and T cell-mediated cytotoxicity by imaging cytometry.通过成像细胞术分析 T 细胞激活和 T 细胞介导的细胞毒性。

J Immunol Methods. 2022 Jul;506:113290. doi: 10.1016/j.jim.2022.113290. Epub 2022 May 27.

The generation and application of antigen-specific T cell therapies for cancer and viral-associated disease.针对癌症和病毒相关疾病的抗原特异性 T 细胞疗法的产生和应用。

Mol Ther. 2022 Jun 1;30(6):2130-2152. doi: 10.1016/j.ymthe.2022.02.002. Epub 2022 Feb 9.

Targeting memory T cell metabolism to improve immunity.靶向记忆 T 细胞代谢以改善免疫。

J Clin Invest. 2022 Jan 4;132(1). doi: 10.1172/JCI148546.

Engineering better chimeric antigen receptor T cells.构建更优的嵌合抗原受体T细胞。

Exp Hematol Oncol. 2020 Dec 2;9(1):34. doi: 10.1186/s40164-020-00190-2.

IL15 Enhances CAR-T Cell Antitumor Activity by Reducing mTORC1 Activity and Preserving Their Stem Cell Memory Phenotype.白细胞介素 15 通过降低 mTORC1 活性和维持其干细胞记忆表型增强 CAR-T 细胞的抗肿瘤活性。

Cancer Immunol Res. 2019 May;7(5):759-772. doi: 10.1158/2326-6066.CIR-18-0466. Epub 2019 Mar 19.

Lymphocytes in Cellular Therapy: Functional Regulation of CAR T Cells.细胞治疗中的淋巴细胞：CAR T 细胞的功能调节。

Front Immunol. 2019 Jan 18;9:3180. doi: 10.3389/fimmu.2018.03180. eCollection 2018.

Redox-responsive interleukin-2 nanogel specifically and safely promotes the proliferation and memory precursor differentiation of tumor-reactive T-cells.氧化还原响应性白细胞介素-2 纳米凝胶特异性且安全地促进了肿瘤反应性 T 细胞的增殖和记忆前体细胞分化。

Biomater Sci. 2019 Mar 26;7(4):1345-1357. doi: 10.1039/c8bm01556b.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Low interleukin-2 concentration favors generation of early memory T cells over effector phenotypes during chimeric antigen receptor T-cell expansion.

作者信息

机构信息

出版信息

相似文献

引用本文的文献

文献检索

文件翻译

深度研究

Suppr 超能文献

相似文献

引用本文的文献