Chen Dongmei, Meng Lin, Pei Fei, Zheng Yang, Leng Jiyan
Department of Cardiology, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, Jilin Province 130021, PR China.
Department of General Internal Medicine, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, Jilin Province 130021, PR China.
J Clin Neurosci. 2017 Sep;43:39-46. doi: 10.1016/j.jocn.2017.05.022. Epub 2017 Jun 20.
As one of the most common psychiatric disorders, depression has been a major public health problem. Growing evidence suggests that epigenetic modification is essential in biological processes of depression. Recently, DNA methylation has been regarded as a potential link between environment and depression. In this review, we reviewed current studies of the association between DNA methylation and depression. The association between DNA methylation of seven genes, including BDNF, SLC6A4, NR3C1, 5-HTR (1A, 2A, and 3A), FKBP5, MAO-A and OXTR, and depression were reviewed in this study. Most studies showed BDNF and NR3C1 gene methylation levels were correlated with depression while the connection of SLC6A4 and depression was conflicting. Although evidence provided insights to epigenetic processes in depression, the findings were inconsistent. Therefore, longitudinal studies in animal models and in patients with depression are needed to further investigate the diagnostic predictive value of DNA methylation reliably.
作为最常见的精神疾病之一，抑郁症一直是一个重大的公共卫生问题。越来越多的证据表明，表观遗传修饰在抑郁症的生物学过程中至关重要。最近，DNA甲基化被认为是环境与抑郁症之间的潜在联系。在本综述中，我们回顾了目前关于DNA甲基化与抑郁症关联的研究。本研究综述了包括BDNF、SLC6A4、NR3C1、5 - HTR（1A、2A和3A）、FKBP5、MAO - A和OXTR在内的七个基因的DNA甲基化与抑郁症之间的关联。大多数研究表明BDNF和NR3C1基因甲基化水平与抑郁症相关，而SLC6A4与抑郁症的联系则存在矛盾。尽管这些证据为抑郁症的表观遗传过程提供了见解，但研究结果并不一致。因此，需要在动物模型和抑郁症患者中进行纵向研究，以进一步可靠地研究DNA甲基化的诊断预测价值。
