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硒缺乏与成年囊性纤维化患者患癌风险可能增加

Selenium deficiency and possible increased risk of carcinoma in adults with cystic fibrosis.

作者信息

Stead R J, Redington A N, Hinks L J, Clayton B E, Hodson M E, Batten J C

出版信息

Lancet. 1985 Oct 19;2(8460):862-3. doi: 10.1016/s0140-6736(85)90127-8.

DOI:10.1016/s0140-6736(85)90127-8
PMID:2864580
Abstract

20 young adults with cystic fibrosis (CF), including 2 with cancer, were found to have low serum selenium concentrations. Serum vitamin E concentrations were also low. It is suggested that low levels of circulating selenium are associated with increased risk of carcinoma, particularly in the presence of reduced vitamin E levels. Older patients with CF may be at increased risk for the development of carcinoma.

摘要

20名患有囊性纤维化(CF)的年轻成年人,其中包括2名患有癌症的患者,被发现血清硒浓度较低。血清维生素E浓度也较低。有人认为,循环硒水平低与患癌风险增加有关,特别是在维生素E水平降低的情况下。年龄较大的CF患者患癌风险可能会增加。

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1
Selenium deficiency and possible increased risk of carcinoma in adults with cystic fibrosis.硒缺乏与成年囊性纤维化患者患癌风险可能增加
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2
[Selenium and vitamin E in mucoviscidosis].
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Selenium deficiency, cystic fibrosis, and pancreatic cancer.硒缺乏、囊性纤维化与胰腺癌。
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Low blood selenium levels in patients with cystic fibrosis compared to controls and healthy adults.与对照组和健康成年人相比,囊性纤维化患者的血硒水平较低。
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Vitamin E status and its determinants in patients with cystic fibrosis.囊性纤维化患者的维生素E状况及其决定因素。
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Risk of cancer in relation to serum concentrations of selenium and vitamins A and E: matched case-control analysis of prospective data.血清硒、维生素A和维生素E浓度与癌症风险的关系:前瞻性数据的配对病例对照分析
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引用本文的文献

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Nutritional immunity: the impact of metals on lung immune cells and the airway microbiome during chronic respiratory disease.营养免疫:金属元素对慢性呼吸系统疾病患者肺部免疫细胞和气道微生物组的影响。
Respir Res. 2021 Apr 29;22(1):133. doi: 10.1186/s12931-021-01722-y.
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Redox balance in cystic fibrosis.囊性纤维化中的氧化还原平衡
Int J Biochem Cell Biol. 2014 Jul;52:113-23. doi: 10.1016/j.biocel.2014.03.006. Epub 2014 Mar 20.
3
Selenium as a chemopreventive agent in experimentally induced colon carcinogenesis.硒作为实验诱导结肠癌发生的化学预防剂。
World J Gastrointest Oncol. 2009 Oct 15;1(1):74-81. doi: 10.4251/wjgo.v1.i1.74.
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Unique presentations and chronic complications in adult cystic fibrosis: do they teach us anything about CFTR?成人囊性纤维化的独特表现和慢性并发症:它们能让我们了解CFTR的相关信息吗?
Respir Res. 2000;1(3):133-5. doi: 10.1186/rr23. Epub 2000 Nov 16.
5
Role of free radicals in the pathogenesis of cystic fibrosis.自由基在囊性纤维化发病机制中的作用。
Thorax. 1994 Aug;49(8):738-42. doi: 10.1136/thx.49.8.738.
6
Practical management of nutrition and gastrointestinal tract in cystic fibrosis.囊性纤维化患者营养与胃肠道的实际管理
J R Soc Med. 1986;79 Suppl 12(Suppl 12):32-5.
7
An overview of the management of cystic fibrosis.囊性纤维化的管理概述。
J R Soc Med. 1986;79 Suppl 12(Suppl 12):55-63.
8
Gastrointestinal tract and nutrition in cystic fibrosis: pathophysiology.囊性纤维化中的胃肠道与营养:病理生理学
J R Soc Med. 1986;79 Suppl 12(Suppl 12):27-31.
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Cystic fibrosis--a gastroenterological cornucopia.囊性纤维化——胃肠病学的丰富宝库。
Gut. 1987 Nov;28(11):1531-47. doi: 10.1136/gut.28.11.1531.
10
[The significance of selenium supply].[硒供应的意义]
Soz Praventivmed. 1989;34(2):71-4. doi: 10.1007/BF02080085.