Perez-Maldonado Ivan N, Ochoa-Martinez Angeles C, Orta-Garcia Sandra T, Ruiz-Vera Tania, Varela-Silva Jose A
Laboratorio de Toxicología Molecular, Centro de Investigación Aplicada en Ambiente y Salud (CIAAS), Coordinación para la Innovación y Aplicación de la Ciencia y la Tecnología (CIACYT), Universidad Autónoma de San Luis Potosí, Avenida Sierra Leona No. 550, Colonia Lomas Segunda Sección, 78210, San Luis Potosí, SLP, Mexico.
Unidad Académica Multidisciplinaria Zona Media, Universidad Autónoma de San Luis Potosí, San Luis Potosí, SLP, Mexico.
Bull Environ Contam Toxicol. 2017 Aug;99(2):258-263. doi: 10.1007/s00128-017-2130-6. Epub 2017 Jun 23.
Human biomonitoring (HBM) is an appreciated tool used to evaluate human exposure to environmental, occupational or lifestyle chemicals. Therefore, the aim of this study was to evaluate the exposure levels for environmental chemicals in urine and blood samples of children from San Luis Potosí, Mexico (SLP). This study identifies environmental chemicals of concern such as: arsenic (45.0 ± 15.0 µg/g creatinine), lead (5.40 ± 2.80 µg/dL), t,t-muconic acid (266 ± 220 µg/g creatinine), 1-hydroxypyrene (0.25 ± 0.15 µmol/mol creatinine), PBDEs (28.0 ± 15.0 ng/g lipid), and PCBs (33.0 ± 16.0 ng/g lipid). On the other hand, low mercury (1.25 ± 1.00 µg/L), hippuric acid (0.38 ± 0.15 µg/g creatinine) and total DDT (130 ± 35 ng/g lipid) exposure levels were found. This preliminary study showed the tool's utility, as the general findings revealed chemicals of concern. Moreover, this screening exhibited the need for HBM in the general population of SLP.
人体生物监测（HBM）是一种用于评估人体接触环境、职业或生活方式相关化学物质的重要工具。因此，本研究旨在评估墨西哥圣路易斯波托西（SLP）儿童尿液和血液样本中环境化学物质的暴露水平。本研究确定了一些值得关注的环境化学物质，如：砷（45.0±15.0微克/克肌酐）、铅（5.40±2.80微克/分升）、反式,反式-粘康酸（266±220微克/克肌酐）、1-羟基芘（0.25±0.15微摩尔/摩尔肌酐）、多溴二苯醚（28.0±15.0纳克/克脂质）和多氯联苯（33.0±16.0纳克/克脂质）。另一方面，发现汞（1.25±1.00微克/升）、马尿酸（0.38±0.15微克/克肌酐）和总滴滴涕（130±35纳克/克脂质）的暴露水平较低。这项初步研究显示了该工具的实用性，因为总体研究结果揭示了一些值得关注的化学物质。此外，这项筛查表明在SLP普通人群中进行人体生物监测的必要性。
