Boedeker N C, Nelson M I, Killian M L, Torchetti M K, Barthel T, Murray S
Smithsonian National Zoo, Washington, DC, USA.
Fogarty International Center, National Institutes of Health, Bethesda, MD, USA.
Zoonoses Public Health. 2017 Nov;64(7):566-571. doi: 10.1111/zph.12370. Epub 2017 Jun 23.
In 2009, a pandemic influenza A virus (pH1N1) spread globally in humans and infected a broad range of captive animals with close human contact. In February 2014, a pH1N1 virus was isolated from a sloth bear with respiratory signs at a US zoo, demonstrating that recurring epidemics present an ongoing threat to animals, including threatened species. This is the first report of pH1N1 infection in sloth bears. To understand the sloth bear virus within the global context of pH1N1, phylogenetic trees were inferred including full-length sequences from available non-human, non-swine hosts, representing four families in the order Carnivora and one order of birds. A combination of phylogenetic and epidemiological evidence strongly suggests the sloth bear was infected with a human-origin pH1N1 virus, supporting the implementation of biosecurity measures to protect human and animal health.
2009年，一种甲型大流行性流感病毒（pH1N1）在全球范围内传播至人类，并感染了众多与人类密切接触的圈养动物。2014年2月，在美国一家动物园里，从一只出现呼吸道症状的懒熊身上分离出了一株pH1N1病毒，这表明反复出现的疫情对包括濒危物种在内的动物构成了持续威胁。这是关于懒熊感染pH1N1的首次报告。为了在pH1N1的全球背景下了解懒熊病毒，构建了系统发育树，纳入了来自可用的非人类、非猪宿主的全长序列，这些宿主代表了食肉目四个科和一个鸟纲。系统发育和流行病学证据相结合，有力地表明懒熊感染了源自人类的pH1N1病毒，这支持了实施生物安全措施以保护人类和动物健康。
