Nigusu Yared, Bekana Teshome, Chilo Eshetu, Teferi Sisay, Donacho Dereje Oljira, Gemeda Dereje, Darge Tefera, Mitiku Abeza, Gedefa Abdi Geda, Sime Tadesse, Gezimu Wubishet, Gizaw Oda, Tadila Gemechu, Bekana Miressa, Erko Berhanu
Department of Medical Laboratory Science, College of Health Sciences, Mattu University, Mattu, Ethiopia.
Department of Health Informatics, College of Health Sciences, Mattu University, Mattu, Ethiopia.
Sci Rep. 2025 Jan 16;15(1):2114. doi: 10.1038/s41598-024-84987-9.
As 2030 approaches, the World Health Organization's due date for ending intestinal schistosomiasis as a public health problem in all endemic areas, understanding the current trends in the burden of schistosomiasis among schoolchildren in endemic areas is critical for monitoring the progress, identifying areas for improvement, and developing strategies to plan for instant response to mitigate the burden of schistosomiasis. From February to April of 2023, 328 students from three primary schools in Southwest Ethiopia participated in an institution-based cross-sectional study in the detection of Schistosoma mansoni. Intestinal schistosomiasis was identified among 242 school children, with a rate of infection of 73.8% (95% CI: (64.8-83.4%)). The rate of infection was higher among study participants aged between 10 and 13 years [AOR = 1.93, 95% CI: (1.1, 3.44). About 75% of the male participants were infected with Schistosoma mansoni [AOR = 0.83, 95% CI (0.49, 1.41). Nearly half (48.1%) of the S. mansoni infections among study participants were identified as heavy infections. More than half of the male study participants (50.3%) infected with Schistosoma mansoni had heavy infection intensity. Of the total female schoolchildren infected with Schistosoma mansoni, about 44.4% had a heavy infection. The prevalence and intensity of infection of Schistosoma mansoni in the study area are significantly noticeable, raising doubts on the effectiveness of the interventional programs or pin-points possible re-infection. Strategies to end the disease as a public health threat, mainly in remote and endemic areas, should consider novel integrated strategies targeting the life cycle of schistosomes besides the large-scale mass drug administration.
随着2030年的临近，这是世界卫生组织设定的在所有流行地区消除肠道血吸虫病这一公共卫生问题的期限，了解流行地区学龄儿童血吸虫病负担的当前趋势对于监测进展、确定改进领域以及制定战略以规划即时应对措施来减轻血吸虫病负担至关重要。2023年2月至4月，埃塞俄比亚西南部三所小学的328名学生参与了一项基于机构的曼氏血吸虫检测横断面研究。在242名学童中发现了肠道血吸虫病，感染率为73.8%（95%置信区间：(64.8 - 83.4%)）。年龄在10至13岁之间的研究参与者感染率更高[AOR = 1.93，95%置信区间：(1.1, 3.44)]。约75%的男性参与者感染了曼氏血吸虫[AOR = 0.83，95%置信区间(0.49, 1.41)]。研究参与者中近一半（48.1%）的曼氏血吸虫感染被确定为重度感染。感染曼氏血吸虫的男性研究参与者中超过一半（50.3%）感染强度为重度。在感染曼氏血吸虫的女性学童中，约44.4%为重度感染。研究区域内曼氏血吸虫的感染率和感染强度非常显著，这对干预项目的有效性提出了质疑，或者指出了可能的再次感染情况。要消除该疾病作为公共卫生威胁，主要是在偏远和流行地区，除大规模群体药物给药外，还应考虑针对血吸虫生命周期的新型综合策略。
