Janssen Research and Development, Johnson and Johnson, Spring House, Pennsylvania, USA.
Department of Medicine, UT Health Science Center, San Antonio, Texas, USA.
Kidney Int. 2017 Jul;92(1):11-13. doi: 10.1016/j.kint.2017.03.023.
Inflammation is an important mediator of most forms of acute kidney injury (AKI). Although neutrophils are prominent components of the inflammatory cascade, the precise role of neutrophils in AKI and the mechanisms by which they contribute to AKI remain controversial. In this issue, Deng et al. identify an important cross talk between renal epithelial cells and neutrophils involving the production and action of leukotriene B4 in mediating cisplatin AKI. We discuss the possible explanations for the discrepant findings that have been reported for neutrophils in cisplatin AKI.
炎症是大多数形式的急性肾损伤 (AKI) 的重要介质。虽然中性粒细胞是炎症级联反应的突出组成部分，但中性粒细胞在 AKI 中的确切作用以及它们导致 AKI 的机制仍存在争议。在本期杂志中，邓等人发现了涉及顺铂 AKI 中白三烯 B4 的产生和作用的肾上皮细胞和中性粒细胞之间的重要串扰。我们讨论了对顺铂 AKI 中性粒细胞的报道存在差异的可能解释。
