Revhaug A, Lygren I, Lundgren T I, Jorde R, Burhol P G, Giercksky K E
Acta Chir Scand. 1985;151(5):401-7.
In an experimental study of hemorrhagic shock, systemic and portal plasma levels of vasoactive intestinal polypeptide (VIP), somatostatin, pancreatic polypeptide (PP), gastric inhibitory peptide (GIP), secretin and insulin were measured with radioimmunoassay methods. Six pigs (30-40 kg) in general anesthesia were submitted to severe hemorrhage (approximately 30% of the blood volume) for 60 min, followed by reinfusion of the shed blood. Aortic blood pressure and cardiac output fell significantly during the shock state and recovered after the infusion. Plasma levels of somatostatin, PP, insulin and secretin rose significantly. The portal levels always presented earlier and greater elevation than did the systemic levels, except as regards secretin. No change was seen in the levels of VIP and GIP.
在一项失血性休克的实验研究中，采用放射免疫测定法测量了血管活性肠肽（VIP）、生长抑素、胰多肽（PP）、胃抑制肽（GIP）、促胰液素和胰岛素的全身及门静脉血浆水平。对6只处于全身麻醉状态的猪（体重30 - 40千克）进行严重出血（约占血容量的30%），持续60分钟，随后回输所流失的血液。休克状态下主动脉血压和心输出量显著下降，输液后恢复。生长抑素、PP、胰岛素和促胰液素的血浆水平显著升高。除促胰液素外，门静脉水平总是比全身水平更早且升高幅度更大。VIP和GIP的水平未见变化。
