Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
J Control Release. 2017 Sep 10;261:43-61. doi: 10.1016/j.jconrel.2017.06.019. Epub 2017 Jun 23.
Disorders of the central nervous system (CNS) represent increasing social and economic problems all over the world which makes the effective transport of drugs to the brain a crucial need. In the last decade, many strategies were introduced to deliver drugs to the brain trying to overcome the challenge of the blood brain barrier (BBB) using both invasive and non-invasive methods. Non-invasive strategy represented in the application of nanocarriers became very common. One of the most hopeful nanoscopic carriers for brain delivery is core-shell nanocarriers or polymeric micelles (PMs). They are more advantageous than other nanocarriers. They offer small size, ease of preparation, ease of sterilization and the possibility of surface modification with various ligands. Hence, the aim of this review is to discuss modern strategies for brain delivery, micelles as a successful delivery system for the brain and how micelles could be modified to act as "magic bullets" for brain delivery.
中枢神经系统（CNS）疾病在全球范围内造成了越来越多的社会和经济问题，因此将药物有效递送到大脑成为了一项关键需求。在过去的十年中，人们采用了许多策略来将药物递送到大脑，试图通过侵入性和非侵入性方法来克服血脑屏障（BBB）的挑战。非侵入性策略体现在纳米载体的应用上变得非常普遍。用于脑递送的最有希望的纳米级载体之一是核壳纳米载体或聚合物胶束（PMs）。它们比其他纳米载体具有更多优势。它们具有尺寸小、易于制备、易于灭菌以及可以用各种配体进行表面修饰的可能性。因此，本文的目的是讨论脑递药的现代策略、胶束作为脑递药的成功载体以及如何修饰胶束使其成为脑递药的“神奇子弹”。
