Yu Dan-Dan, Ren Qiong-Qiong, Dong Bao, Zhao Dong-Dong, Sun Ye-Huan
Department of Epidemiology and Health Statistics, Anhui Medical University, Hefei, China.
Department of Epidemiology and Health Statistics, Anhui Medical University, Hefei, China; Centre for Evidence-Based Practice, Anhui Medical University, Hefei, China.
J Stroke Cerebrovasc Dis. 2017 Oct;26(10):2354-2361. doi: 10.1016/j.jstrokecerebrovasdis.2017.05.024. Epub 2017 Jun 22.
The association between cholesteryl ester transfer protein (CETP) TaqIB polymorphism and ischemic stroke (IS) risk has generated conflicting results. To investigate whether the TaqIB polymorphism of the CETP gene was associated with the risk of IS, a meta-analysis was performed.
Studies were retrieved by searching PubMed, Web of Science, the Chinese National Knowledge Infrastructure, the Chinese Wanfang Database, and the Chinese VIP Database before January 16, 2017. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were used to assess the association. Depending on the heterogeneity the fixed-effects model or the random-effects model was used.
A total of 6 case-control studies were identified with 1494 cases and 1370 controls. Overall, an association of CETP TaqIB polymorphism with IS was found in the 4 genetic models (B2B2 versus B1B1: OR = .63, 95% CI = .51-.79, P < .001; B1B2 + B2B2 versus B1B1: OR = .75, 95% CI = .64-.87, P < .001; B2B2 versus B1B2 + B1B1: OR = .70, 95% CI = .57-.85, P < .001; B2 versus B1: OR = .78, 95% CI = .70-.87, P < .001). In the subgroup analysis by ethnicity, similar risks were also observed in Asian population.
This meta-analysis indicates that CETP TaqIB polymorphism is associated with IS risk, and the B2 allele is a protective factor for IS.
胆固醇酯转运蛋白（CETP）TaqIB基因多态性与缺血性卒中（IS）风险之间的关联产生了相互矛盾的结果。为了研究CETP基因的TaqIB多态性是否与IS风险相关，进行了一项荟萃分析。
通过检索2017年1月16日前的PubMed、科学网、中国知网、中国万方数据库和中国维普数据库来获取研究。采用比值比（OR）和95%置信区间（95%CI）来评估这种关联。根据异质性情况使用固定效应模型或随机效应模型。
共纳入6项病例对照研究，包括1494例病例和1370例对照。总体而言，在4种遗传模型中发现CETP TaqIB多态性与IS存在关联（B2B2与B1B1相比：OR = 0.63，95%CI = 0.51 - 0.79，P < 0.001；B1B2 + B2B2与B1B1相比：OR = 0.75，95%CI = 0.64 - 0.87，P < 0.001；B2B2与B1B2 + B1B1相比：OR = 0.70，95%CI = 0.57 - 0.85，P < 0.001；B2与B1相比：OR = 0.78，95%CI = 0.70 - 0.87，P < 0.001）。在按种族进行的亚组分析中，亚洲人群也观察到类似的风险。
这项荟萃分析表明，CETP TaqIB多态性与IS风险相关，且B2等位基因是IS的一个保护因素。
