Cao Min, Zhou Zhi-Wen, Fang Bang-Jiang, Zhao Cheng-Gen, Zhou Duan
From the Department of Emergency, Longhua Hospital Afflicted to Shanghai University of Traditional Chinese Medcine (MC, J-BF); Department of Cardiology, Xuhui District Central Hospital, Shanghai, China (Z-W Z); Department of Traditional Chinese Medicine, Putuo Hospital Afflicted to Shanghai University of Traditional Chinese Medcine (G-GZ); and Department of Cardiology, Longhua Hospital Afflicted to Shanghai University of Traditional Chinese Medcine, Shanghai (DZ), China.
Medicine (Baltimore). 2014 Nov;93(26):e160. doi: 10.1097/MD.0000000000000160.
A number of studies have been conducted to explore the association between the cholesteryl ester transfer protein (CETP) TaqIB polymorphism and risk of myocardial infarction (MI); however, the results are inconsistent. Therefore, we conducted this meta-analysis to clarify the issue based on all the data available.Eligible studies were retrieved by searching PubMed, Embase, Web of Science, and Google Scholar. We calculated the crude odds ratios (ORs) and corresponding 95% confidence intervals (95% CIs) to assess the association between the TaqIB polymorphism and risk of MI.We included 13 studies involving 8733 MI cases and 8573 controls in the meta-analysis. The pooled results from all included studies showed decreased MI risk in the analysis of the B2B2 versus B1B1 (OR = 0.78, 95% CI = 0.68-0.91), dominant (OR = 0.88, 95% CI = 0.77-0.99), and recessive genetic models (OR = 0.84, 95% CI = 0.78-0.91). The frequency of the B2B2 genotype in MI patients was lower (OR = 0.87, 95% CI = 0.81-0.94). However, there was no significant association in the B1B2 versus B1B1 analysis (OR = 0.92, 95% CI = 0.81-1.05) and no significant difference for the B1B1 genotype (OR = 1.04, 95% CI = 0.98-1.11) and B1B2 genotype (OR = 1.03, 95% CI = 0.97-1.08). Cumulative analysis confirmed these results.Our results suggest that the B2B2 genotype of the CETP TaqIB polymorphism is a protective factor against the development of MI.
已经开展了多项研究来探索胆固醇酯转运蛋白（CETP）TaqIB基因多态性与心肌梗死（MI）风险之间的关联；然而，结果并不一致。因此，我们进行了这项荟萃分析，以根据所有可用数据阐明该问题。通过检索PubMed、Embase、Web of Science和谷歌学术搜索来获取符合条件的研究。我们计算了粗比值比（OR）和相应的95%置信区间（95%CI），以评估TaqIB基因多态性与MI风险之间的关联。我们在荟萃分析中纳入了13项研究，涉及8733例MI病例和8573例对照。所有纳入研究的汇总结果显示，在B2B2与B1B1分析（OR = 0.78，95%CI = 0.68 - 0.91）、显性遗传模型（OR = 0.88，95%CI = 0.77 - 0.99）和隐性遗传模型（OR = 0.84，95%CI = 0.78 - 0.91）中，MI风险降低。MI患者中B2B2基因型的频率较低（OR = 0.87，95%CI = 0.81 - 0.94）。然而，在B1B2与B1B1分析中无显著关联（OR = 0.92，95%CI = 0.81 - 1.05），并且B1B1基因型（OR = 1.04，95%CI = 0.98 - 1.11）和B1B2基因型（OR = 1.03，95%CI = 0.97 - 1.08）无显著差异。累积分析证实了这些结果。我们的结果表明，CETP TaqIB基因多态性的B2B2基因型是预防MI发生的一个保护因素。
