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产气荚膜梭菌介导鹅去氧胆酸C-3位差向异构化机制的研究

A study on the mechanism of the epimerization at C-3 of chenodeoxycholic acid by Clostridium perfringens.

作者信息

Aragozzini F, Canzi E, Ferrari A, Maconi E, Sidjimov A

出版信息

Biochem J. 1985 Sep 1;230(2):451-5. doi: 10.1042/bj2300451.

DOI:10.1042/bj2300451
PMID:2864922
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1152636/
Abstract

The mechanism of 3-hydroxy epimerization of chenodeoxycholic acid by Clostridium perfringens was investigated in 3 alpha, 7 alpha-dihydroxy-[2,2,4,4-2H4]-, 3 alpha, 7 alpha-dihydroxy-[3 beta-2H]- and 3 beta, 7 alpha-dihydroxy-[3 alpha-2H]-5 beta-cholanoic acid transformations. Our findings rule out a dehydration-rehydration pathway and agree with a redox mechanism involving 3-oxochenodeoxycholic acid as intermediate.

摘要

在3α,7α-二羟基-[2,2,4,4-2H4]-、3α,7α-二羟基-[3β-2H]-和3β,7α-二羟基-[3α-2H]-5β-胆烷酸转化过程中，研究了产气荚膜梭菌使鹅去氧胆酸发生3-羟基差向异构化的机制。我们的研究结果排除了脱水-再水化途径，与以3-氧代鹅去氧胆酸为中间体的氧化还原机制相符。

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本文引用的文献

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Reversible enzymatic oxidation of bile acids.胆汁酸的可逆酶促氧化
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Increased formation of ursodeoxycholic acid in patients treated with chenodeoxycholic acid.用鹅去氧胆酸治疗的患者中熊去氧胆酸的生成增加。
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Bile induction of 7 alpha- and 7 beta-hydroxysteroid dehydrogenases in Clostridium absonum.胆汁诱导隐匿梭菌中7α-和7β-羟基类固醇脱氢酶的产生
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Formation of urso- and ursodeoxy-cholic acids from primary bile acids by Clostridium absonum.阿氏梭菌将初级胆汁酸转化为熊去氧胆酸和熊脱氧胆酸。
J Lipid Res. 1981 Mar;22(3):458-66.
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A study of the maloalcoholic fermentation pathway in Schizosaccharomyces pombe.粟酒裂殖酵母中苹果酸酒精发酵途径的研究。
Biochem J. 1984 Jan 15;217(2):585-8. doi: 10.1042/bj2170585.
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Transformation of bile acids by Clostridium perfringens.产气荚膜梭菌对胆汁酸的转化作用。
Appl Environ Microbiol. 1981 Sep;42(3):394-9. doi: 10.1128/aem.42.3.394-399.1981.
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Chenodeoxycholic acid treatment of gallstones. A follow-up report and analysis of factors influencing response to therapy.鹅去氧胆酸治疗胆结石。随访报告及影响治疗反应因素的分析。
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