Carvalho Larissa F, Silva Ana Maria F, Carvalho Adriana A
Federal University of Sergipe, Department of Medicine, Post Graduation Program in Health Sciences, São Cristóvão, Sergipe, Brazil.
Federal University of Sergipe, Department of Pharmacy, Lagarto, Sergipe, Brazil.
Clin Exp Pharmacol Physiol. 2017 Oct;44(10):971-979. doi: 10.1111/1440-1681.12803. Epub 2017 Aug 24.
Antineoplastic drugs such as cisplatin, oxaliplatin, paclitaxel and vincristin are widely used in the treatment of several solid and blood tumours. However, the severity of peripheral neuropathy caused by these agents can affect the patient's quality of life. The major symptoms of chemotherapy-induced peripheral neuropathy (CIPN) involve: sensory loss, paresthesia, dysesthaesia, numbness, tingling, temperature sensitivity, allodynia and hyperalgesia, in a "stocking and glove" distribution. Why many different chemotherapeutic agents result in similar neuropathy profiles is unclear. Many drug classes such as antidepressants, anticonvulsants, antispastic agents and others have been used in clinical practice, but there is no scientific evidence to prove their effectiveness. But drugs as the antioxidant have shown a protective effect against free radical damage. In order to find out a successful treatment for CIPN, animal studies (ie pharmacological and mechanical tests and histopathological immunohistochemical analyses) have been developed to try to determinate the action of the antioxidant agents. This review provides an overview of the major antioxidant agents recently investigated to treat CIPN and the animal models used for this purpose.
顺铂、奥沙利铂、紫杉醇和长春新碱等抗肿瘤药物广泛应用于多种实体瘤和血液肿瘤的治疗。然而，这些药物引起的外周神经病变的严重程度会影响患者的生活质量。化疗诱导的外周神经病变（CIPN）的主要症状包括：感觉丧失、感觉异常、感觉障碍、麻木、刺痛、温度敏感、痛觉过敏和痛觉超敏，呈“手套和袜套”样分布。目前尚不清楚为何许多不同的化疗药物会导致相似的神经病变表现。临床实践中已使用了许多类药物，如抗抑郁药、抗惊厥药、抗痉挛药等，但尚无科学证据证明其有效性。但抗氧化剂类药物已显示出对自由基损伤的保护作用。为了找到治疗CIPN的成功方法，已开展了动物研究（即药理学和力学测试以及组织病理学免疫组织化学分析），试图确定抗氧化剂的作用。本综述概述了最近研究用于治疗CIPN的主要抗氧化剂以及为此目的使用的动物模型。
