Pittsburgh Center for Pain Research, and the Pittsburgh Project to End Opioid Misuse, Department of Anesthesiology & Perioperative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Department of Biology, Texas Woman's University, Denton, TX 76204-5799, USA.
Int J Mol Sci. 2021 Apr 28;22(9):4666. doi: 10.3390/ijms22094666.
Lesion or disease of the somatosensory system leads to the development of neuropathic pain. Peripheral neuropathic pain encompasses damage or injury of the peripheral nervous system. On the other hand, 10-15% of individuals suffer from acute postoperative pain followed by persistent pain after undergoing surgeries. Antidepressants, anticonvulsants, baclofen, and clonidine are used to treat peripheral neuropathy, whereas opioids are used to treat postoperative pain. The negative effects associated with these drugs emphasize the search for alternative therapeutics with better efficacy and fewer side effects. Curcumin, a polyphenol isolated from the roots of possesses antibacterial, antioxidant, and anti-inflammatory properties. Furthermore, the low bioavailability and fast metabolism of curcumin have led to the advent of various curcumin formulations. The present review provides a comprehensive analysis on the effects of curcumin and its formulations in preclinical and clinical studies of neuropathic and postoperative pain. Based on the positive outcomes from both preclinical and clinical studies, curcumin holds the promise of mitigating or preventing neuropathic and postoperative pain conditions. However, more clinical studies with improved curcumin formulations are required to involve its use as adjuvant to neuropathic and postoperative drugs.
躯体感觉系统的损伤或疾病会导致神经性疼痛的发生。周围神经性疼痛包括周围神经系统的损伤或损伤。另一方面，10-15%的人在手术后会经历急性术后疼痛，随后会持续疼痛。抗抑郁药、抗惊厥药、巴氯芬和可乐定用于治疗周围神经病变，而阿片类药物用于治疗术后疼痛。这些药物的副作用强调了寻找疗效更好、副作用更少的替代疗法的必要性。姜黄素是从姜黄根茎中分离出来的一种多酚，具有抗菌、抗氧化和抗炎特性。此外，姜黄素的生物利用度低和代谢快导致了各种姜黄素制剂的出现。本综述全面分析了姜黄素及其制剂在神经性和术后疼痛的临床前和临床研究中的作用。基于临床前和临床研究的积极结果，姜黄素有望减轻或预防神经性和术后疼痛。然而，需要更多的临床研究来改进姜黄素制剂，以将其作为辅助药物用于治疗神经性和术后疼痛。
