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Synthesis, evaluation of cytotoxic properties of promising curcumin analogues and investigation of possible molecular mechanisms.合成、评估有前景的姜黄素类似物的细胞毒性性质，并研究可能的分子机制。
Chem Biol Drug Des. 2018 Jan;91(1):332-337. doi: 10.1111/cbdd.13061. Epub 2017 Jul 18.
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Synthesis, cytotoxicity of new 4-arylidene curcumin analogues and their multi-functions in inhibition of both NF-κB and Akt signalling.新型 4-芳基二氢姜黄素类似物的合成、细胞毒性及其对 NF-κB 和 Akt 信号通路的双重抑制作用的多功能研究。
Eur J Med Chem. 2012 Sep;55:346-57. doi: 10.1016/j.ejmech.2012.07.039. Epub 2012 Jul 31.
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Structurally modified curcumin analogs inhibit STAT3 phosphorylation and promote apoptosis of human renal cell carcinoma and melanoma cell lines.结构修饰姜黄素类似物抑制 STAT3 磷酸化并促进人肾细胞癌细胞系和黑色素瘤细胞系的凋亡。
PLoS One. 2012;7(8):e40724. doi: 10.1371/journal.pone.0040724. Epub 2012 Aug 10.
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Discovery of monocarbonyl curcumin-BTP hybrids as STAT3 inhibitors for drug-sensitive and drug-resistant breast cancer therapy.发现单羰基姜黄素-BTP 杂化物作为 STAT3 抑制剂，用于治疗敏感和耐药性乳腺癌。
Sci Rep. 2017 Apr 11;7:46352. doi: 10.1038/srep46352.
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Sensitization of head and neck cancer to cisplatin through the use of a novel curcumin analog.通过使用一种新型姜黄素类似物使头颈癌对顺铂敏感。
Arch Otolaryngol Head Neck Surg. 2011 May;137(5):499-507. doi: 10.1001/archoto.2011.63.
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Targeting constitutive and interleukin-6-inducible signal transducers and activators of transcription 3 pathway in head and neck squamous cell carcinoma cells by curcumin (diferuloylmethane).姜黄素（二阿魏酰甲烷）对头颈部鳞状细胞癌细胞中组成型和白细胞介素-6诱导型信号转导子及转录激活子3通路的靶向作用
Int J Cancer. 2006 Sep 15;119(6):1268-75. doi: 10.1002/ijc.21967.
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New curcumin analogues exhibit enhanced growth-suppressive activity and inhibit AKT and signal transducer and activator of transcription 3 phosphorylation in breast and prostate cancer cells.新型姜黄素类似物在乳腺癌和前列腺癌细胞中表现出增强的生长抑制活性，并抑制AKT以及信号转导和转录激活因子3的磷酸化。
Cancer Sci. 2009 Sep;100(9):1719-27. doi: 10.1111/j.1349-7006.2009.01220.x. Epub 2009 May 18.
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Synthesis and biological evaluation of some novel triazole hybrids of curcumin mimics and their selective anticancer activity against breast and prostate cancer cell lines.一些新型姜黄素模拟物三唑杂化物的合成及其对乳腺癌和前列腺癌细胞系的选择性抗癌活性的生物学评价。
Bioorg Med Chem Lett. 2016 Sep 1;26(17):4223-32. doi: 10.1016/j.bmcl.2016.07.053. Epub 2016 Jul 25.
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Design and Synthesis of Curcumin-Like Diarylpentanoid Analogues as Potential Anticancer Agents.姜黄素类二芳基戊烷类似物作为潜在抗癌剂的设计与合成
Recent Pat Anticancer Drug Discov. 2016;11(3):342-51. doi: 10.2174/1574892811666160420141613.
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Half-Sandwich Ruthenium and Osmium Complexes with Hydrazinocurcuminoid-like Ligands.具有肼基姜黄素类配体的半夹心钌和锇配合物
Organometallics. 2025 May 16;44(11):1155-1164. doi: 10.1021/acs.organomet.5c00082. eCollection 2025 Jun 9.
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Combination of Lycopene and Curcumin Synergistically Alleviates Testosterone-Propionate-Induced Benign Prostatic Hyperplasia in Sprague Dawley Rats via Modulating Inflammation and Proliferation.番茄红素和姜黄素的联合使用通过调节炎症和增殖协同缓解丙酸睾酮诱导的 Sprague Dawley 大鼠良性前列腺增生。
Molecules. 2023 Jun 21;28(13):4900. doi: 10.3390/molecules28134900.
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Synthesis of aspirin-curcumin mimic conjugates of potential antitumor and anti-SARS-CoV-2 properties.合成具有潜在抗肿瘤和抗 SARS-CoV-2 性质的阿司匹林-姜黄素模拟缀合物。
Bioorg Chem. 2021 Dec;117:105466. doi: 10.1016/j.bioorg.2021.105466. Epub 2021 Nov 4.
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Perspectives for synthetic curcumins in chemoprevention and treatment of cancer: An update with promising analogues.合成姜黄素在癌症化学预防和治疗中的展望：具有前景的类似物的更新。
Eur J Pharmacol. 2021 Sep 5;906:174266. doi: 10.1016/j.ejphar.2021.174266. Epub 2021 Jun 17.
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The Curcumin Analog CH-5 Exerts Anticancer Effects in Human Osteosarcoma Cells via Modulation of Transcription Factors p53/Sp1.姜黄素类似物 CH-5 通过调节转录因子 p53/Sp1 发挥对人骨肉瘤细胞的抗癌作用。
Int J Mol Sci. 2018 Jun 29;19(7):1909. doi: 10.3390/ijms19071909.
本文引用的文献
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Recent Advances of Curcumin and its Analogues in Breast Cancer Prevention and Treatment.姜黄素及其类似物在乳腺癌预防和治疗中的最新进展
RSC Adv. 2015;5(92):75575-75588. doi: 10.1039/C5RA14925H. Epub 2015 Sep 2.
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Molecular mechanisms of curcumin and its semisynthetic analogues in prostate cancer prevention and treatment.姜黄素及其半合成类似物在前列腺癌预防和治疗中的分子机制
Life Sci. 2016 May 1;152:135-44. doi: 10.1016/j.lfs.2016.03.036. Epub 2016 Mar 24.
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Synthesis and evaluation of 1,7-diheteroarylhepta-1,4,6-trien-3-ones as curcumin-based anticancer agents.基于姜黄素的抗癌剂1,7-二杂芳基庚-1,4,6-三烯-3-酮的合成与评价
Eur J Med Chem. 2016 Mar 3;110:164-80. doi: 10.1016/j.ejmech.2016.01.017. Epub 2016 Jan 21.
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Cancer statistics, 2016.癌症统计数据，2016 年。
CA Cancer J Clin. 2016 Jan-Feb;66(1):7-30. doi: 10.3322/caac.21332. Epub 2016 Jan 7.
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Performance evaluation of structure based and ligand based virtual screening methods on ten selected anti-cancer targets.基于结构和基于配体的虚拟筛选方法对十个选定抗癌靶点的性能评估
Bioorg Med Chem Lett. 2015 Oct 15;25(20):4632-6. doi: 10.1016/j.bmcl.2015.08.040. Epub 2015 Aug 20.
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Structure-Activity Relationship and Pharmacokinetic Studies of 1,5-Diheteroarylpenta-1,4-dien-3-ones: A Class of Promising Curcumin-Based Anticancer Agents.1,5-二杂芳基戊-1,4-二烯-3-酮类化合物的构效关系及药代动力学研究：一类有前景的基于姜黄素的抗癌剂
J Med Chem. 2015 Jun 11;58(11):4713-26. doi: 10.1021/acs.jmedchem.5b00470. Epub 2015 May 22.
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Curcumin-based anti-prostate cancer agents.基于姜黄素的抗前列腺癌药物。
Anticancer Agents Med Chem. 2015;15(2):138-56. doi: 10.2174/1871520615666150116102442.
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A novel curcumin analog (H-4073) enhances the therapeutic efficacy of cisplatin treatment in head and neck cancer.一种新型姜黄素类似物（H-4073）可增强顺铂治疗头颈部癌的疗效。
PLoS One. 2014 Mar 27;9(3):e93208. doi: 10.1371/journal.pone.0093208. eCollection 2014.
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Design, synthesis, and evaluation of novel heteroaromatic analogs of curcumin as anti-cancer agents.姜黄素新型杂芳族类似物作为抗癌剂的设计、合成与评估。
Eur J Med Chem. 2014 Mar 21;75:123-31. doi: 10.1016/j.ejmech.2014.01.041. Epub 2014 Jan 29.
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Synthesis and antibacterial activity of novel curcumin derivatives containing heterocyclic moiety.含杂环部分的新型姜黄素衍生物的合成及其抗菌活性
Iran J Pharm Res. 2013 Winter;12(1):47-56.
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