Wu Weiguang, Fan Xiaobin, Yu Yuecheng, Wang Zheng, Wang Yingchun
a Department of Obstetrics and Gynecology , Affiliated Hospital, Logistical College of Chinese People's Armed Police Forces , Tianjin , PR China.
b Department of Obstetrics and Gynecology , Xi'an No3 Hospital , Shanxi Xi'an , PR China.
Gynecol Endocrinol. 2018 Jan;34(1):36-39. doi: 10.1080/09513590.2017.1336216. Epub 2017 Jun 24.
Ghrelin, an endoggenous for the growth hormone secretagogue receptor, has been shown to participate in the regulation of energy homeostasis and pituitary hormone secretion. Obestatin, encoded by the same gene as ghrelin, is described as a physiological opponent of ghrelin. Ghrelin and obestatin are altered in polycystic ovary syndrome (PCOS), which is characterized by insulin resistance and pituitary hormone secretion disorder. The aim of this study was to evaluate ghrelin/obestatin imbalance in relation to insulin resistance and pituitary hormone in adolescence with PCOS. This restrospective case-control study included 33 adolescence with PCOS and 38 control adolescence. Ghrelin and obestatin concentrations in serum were determined by RIA, and the serum fasting glucose and Insulin were determined by the glucose oxidase color method and INS-EASIA. The serum LH and FSH were measured by highly specific hemiluminescence immunoassays. We found that the serum ghrelin levels and ghrelin/obestatin ratio were significant lower in PCOS group than in control group, and the serum obestatin levels were significant higher in PCOS group than in control group. The ghrelin/obestatin ratios were negatively correlation with LH/FSH ratio and insulin resistant index in PCOS group. The findings of this study suggest that ghrelin/obestatin imbalance may play a role in pathogenesis of adolescent PCOS.
胃饥饿素是生长激素促分泌素受体的内源性配体，已被证明参与能量稳态调节和垂体激素分泌。由与胃饥饿素相同的基因编码的肥胖抑制素被描述为胃饥饿素的生理拮抗剂。多囊卵巢综合征（PCOS）患者存在胃饥饿素和肥胖抑制素的改变，该疾病以胰岛素抵抗和垂体激素分泌紊乱为特征。本研究的目的是评估青春期PCOS患者中胃饥饿素/肥胖抑制素失衡与胰岛素抵抗及垂体激素的关系。这项回顾性病例对照研究纳入了33例青春期PCOS患者和38例对照青春期女性。采用放射免疫分析法测定血清中胃饥饿素和肥胖抑制素浓度，采用葡萄糖氧化酶比色法和胰岛素酶联免疫吸附测定法测定血清空腹血糖和胰岛素。采用高特异性半发光免疫分析法测定血清促黄体生成素（LH）和促卵泡生成素（FSH）。我们发现，PCOS组血清胃饥饿素水平和胃饥饿素/肥胖抑制素比值显著低于对照组，PCOS组血清肥胖抑制素水平显著高于对照组。PCOS组胃饥饿素/肥胖抑制素比值与LH/FSH比值及胰岛素抵抗指数呈负相关。本研究结果表明，胃饥饿素/肥胖抑制素失衡可能在青春期PCOS发病机制中起作用。
