a Institute of Tropical Agriculture and Food Security, Universiti Putra Malaysia , Serdang , Selangor , Malaysia.
b Department of Crop Science, Faculty of Agriculture , Universiti Putra Malaysia , Serdang , Selangor , Malaysia.
Biotechnol Genet Eng Rev. 2017 Apr;33(1):26-39. doi: 10.1080/02648725.2017.1340546. Epub 2017 Jun 25.
Studying the strategies of improving abiotic stress tolerance is quite imperative and research under this field will increase our understanding of response mechanisms to abiotic stress such as heat. The Hsp70 is an essential regulator of protein having the tendency to maintain internal cell stability like proper folding protein and breakdown of unfolded proteins. Hsp70 holds together protein substrates to help in movement, regulation, and prevent aggregation under physical and or chemical pressure. However, this review reports the molecular mechanism of heat shock protein 70 kDa (Hsp70) action and its structural and functional analysis, research progress on the interaction of Hsp70 with other proteins and their interaction mechanisms as well as the involvement of Hsp70 in abiotic stress responses as an adaptive defense mechanism.
研究提高非生物胁迫耐受性的策略是非常必要的,这一领域的研究将增进我们对非生物胁迫(如热胁迫)响应机制的理解。Hsp70 是一种重要的调节蛋白,它有维持细胞内稳定性的倾向,如正确折叠的蛋白质和未折叠蛋白质的降解。Hsp70 将蛋白质底物结合在一起,有助于在物理和化学压力下的运动、调节和防止聚集。然而,本综述报告了热休克蛋白 70 kDa(Hsp70)作用的分子机制及其结构和功能分析,研究了 Hsp70 与其他蛋白质的相互作用及其相互作用机制,以及 Hsp70 参与非生物胁迫响应作为一种适应性防御机制。