Laboratoire des Polymères, Institut des Matériaux and Institut des Sciences et Ingénierie Chimiques, École Polytechnique Fédérale de Lausanne (EPFL) , Bâtiment MXD, Station 12, CH-1015 Lausanne, Switzerland.
Division Recherche & Développement, Firmenich SA , Route des Jeunes 1, CH-1211 Genève, Switzerland.
ACS Appl Mater Interfaces. 2017 Jul 19;9(28):24238-24249. doi: 10.1021/acsami.7b06569. Epub 2017 Jul 6.
The deposition of fragrance delivery systems onto human hair from a shampoo formulation is a challenging task, as the primary function of shampoo is to cleanse the hair by removing primarily hydrophobic moieties. In this work, to tackle this challenge, phage-display-identified peptides that can bind to human hair under shampooing conditions are first identified and subsequently used to enhance the deposition of model fragrance delivery systems. These delivery systems are based on either poly(N-(2-hydroxypropyl)methacrylamide) (PHPMA) copolymers as a representative for polymeric profragrances or polyurethane/polyurea-type core-shell microcapsules as a model physical fragrance carrier. The incorporation of a hair-binding peptide enhanced the deposition of PHPMA copolymers by a factor of 3.5-5.0 depending on the extent of peptide incorporation, whereas 10 wt % surface functionalization of microcapsules with the peptide led to a 20-fold increase in their deposition. In a final experiment, treatment of the hair samples under realistic application conditions with the peptide-functionalized microcapsules resulted in an increase in fragrance release from the hair surfaces.
从洗发水配方中将香味传递系统沉积到人类头发上是一项具有挑战性的任务，因为洗发水的主要功能是通过去除主要的疏水性部分来清洁头发。在这项工作中，为了应对这一挑战，首先鉴定了能够在洗发条件下与人发结合的噬菌体展示鉴定肽，随后将其用于增强模型香味传递系统的沉积。这些传递系统基于聚（N-（2-羟丙基）甲基丙烯酰胺）（PHPMA）共聚物作为聚合型前体的代表，或基于聚氨酯/聚脲型核壳微胶囊作为物理型香味载体的模型。根据肽的掺入程度，掺入毛发结合肽可将 PHPMA 共聚物的沉积增强 3.5-5.0 倍，而用肽对微胶囊进行 10wt%的表面功能化可使它们的沉积增加 20 倍。在最后的实验中，用肽功能化的微胶囊对头发样本进行现实应用条件下的处理，导致头发表面的香味释放增加。
