Miura Y
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1985;82(1):63-7.
The content of cytochrome P-450 and the specific activity of laurate hydroxylation have been measured at monthly intervals through the year in liver microsomes of males and females of Japanese bullfrog, Rana catesbeiana. The specific activity, based on microsomal protein or cytochrome P-450 of both sexes was higher in spring (April-May) than in autumn (October-November) and the difference was statistically significant. However, in males the content of the cytochrome P-450 in the spring was almost the same level as in the autumn and it was rather lower in the spring than in the autumn in females. These suggest that the cytochrome P-450 species catalyzing laurate hydroxylation increased specifically in the spring. The specific activity (based on cytochrome P-450) in males was significantly higher than that in females in spring (April-May) or autumn (October-November).
在一年中，每月都对日本牛蛙（Rana catesbeiana）雄性和雌性个体肝脏微粒体中细胞色素P - 450的含量以及月桂酸羟化的比活性进行测定。基于两性微粒体蛋白或细胞色素P - 450的比活性在春季（4 - 5月）高于秋季（10 - 11月），且差异具有统计学意义。然而，雄性个体春季细胞色素P - 450的含量与秋季几乎处于同一水平，而雌性个体春季的含量则比秋季更低。这些结果表明，催化月桂酸羟化的细胞色素P - 450种类在春季特异性增加。在春季（4 - 5月）或秋季（10 - 11月），雄性个体基于细胞色素P - 450的比活性显著高于雌性个体。
