Wollin Daniel A, Skolarikos Andreas, Preminger Glenn M
aDivision of Urologic Surgery, Duke Comprehensive Kidney Stone Center, Durham, North Carolina, USA bDepartment of Urology, National and Kapodistrian University of Athens, Athens, Greece.
Curr Opin Urol. 2017 Sep;27(5):422-427. doi: 10.1097/MOU.0000000000000427.
In this article, we aim to review the data regarding associations between obesity and nephrolithiasis to assist with workup and treatment of these intersecting disorders. As obesity has a multifactorial influence on the risk for urinary stone disease, the complicated mechanisms will be discussed to improve diagnosis and management.
Obesity and metabolic syndrome interact with nephrolithiasis risk factors to produce a myriad of bodily responses that induce stone formation. For this reason, many societies recommend prompt metabolic workup to evaluate the precise causes of stone formation. Data have shown that dietary and directed medical therapies can produce an excellent therapeutic response in this patient population, although the response may be blunted compared with nonobese patients.
Given the increasing number of obese and overweight patients, the urologist should be familiar with the pathophysiology, workup, and treatment of metabolic stone disease in this population, which are outlined here.
在本文中，我们旨在回顾肥胖与肾结石之间关联的数据，以协助对这些交叉疾病进行检查和治疗。由于肥胖对尿石症风险具有多因素影响，将讨论其复杂机制以改善诊断和管理。
肥胖和代谢综合征与肾结石危险因素相互作用，产生多种导致结石形成的身体反应。因此，许多学会建议进行快速代谢检查以评估结石形成的确切原因。数据表明，饮食和针对性药物治疗在该患者群体中可产生良好的治疗反应，尽管与非肥胖患者相比，反应可能会减弱。
鉴于肥胖和超重患者数量不断增加，泌尿外科医生应熟悉该人群代谢性结石病的病理生理学、检查和治疗，本文对此进行了概述。
