Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Curr Opin Urol. 2012 Mar;22(2):154-9. doi: 10.1097/MOU.0b013e32834fc31f.
This review describes the relationship between nephrolithiasis, vascular disease and metabolic syndrome.
There is increasing evidence that kidney stone formation is associated with a number of systemic problems including cardiovascular disease, metabolic syndrome and its components. Some of these associations are bidirectional. The reasons for these associations are not totally clear, but potential factors include metabolic responses associated with these disorders that promote a stone forming milieu in urine, environmental factors such as diet, oxidative stress and inflammation and molecular changes impacting the transport of certain analytes in urine.
Urologists need to be cognizant of these associations as they may be able to contribute to an early diagnosis of a significant medical problem, or provide counseling to patients to prevent their occurrence.
本文描述了肾结石、血管疾病和代谢综合征之间的关系。
越来越多的证据表明肾结石的形成与许多系统性问题有关，包括心血管疾病、代谢综合征及其组成部分。其中一些关联是双向的。这些关联的原因尚不完全清楚，但潜在的因素包括与这些疾病相关的代谢反应，这些反应促进了尿液中结石形成的环境，以及饮食、氧化应激和炎症等环境因素和影响尿液中某些分析物转运的分子变化。
泌尿科医生需要意识到这些关联，因为它们可能有助于早期诊断重大医疗问题，或为预防这些问题的发生向患者提供咨询。
