健康筛查人群中代谢综合征与肾结石的发病率及相关性
Incidence and correlation of metabolic syndrome and kidney stones in a healthy screening population.
作者信息
Qiu Feng, Xu Yunfeng, Ji Xiaodong, Pu Jinxian, Zhou Jian, Huang Yuhua
机构信息
Department of Urology, the First Affiliated Hospital of Soochow University, Suzhou, China.
Department of Urology, KunShan Second People's Hospital, Suzhou, China.
出版信息
Transl Androl Urol. 2021 Sep;10(9):3646-3655. doi: 10.21037/tau-21-689.
BACKGROUND
To study the incidence of metabolic syndrome (MetS) and kidney stones in a healthy screening population and to explore the correlation between them.
METHODS
The physical examination data of 11,827 people screened at the First Affiliated Hospital of Soochow University from August 2019 to July 2020 were analyzed. MetS diagnostic criteria were based on the 2004 guidelines of Chinese Diabetes Society (CDS). Multivariate logistic regression was used to analyze the correlation between MetS and various characteristics and kidney stones. Trend analysis was represented by P value, and P<0.05 indicated statistical significance.
RESULTS
The present study comprised 6,570 males (55.6%, aged 46.15±13.653 years) and 5,257 females (44.4%, aged 41.41±11.712 years). Of these, 1,036 (8.8%) had kidney stones and 1,552 (13.1%) had MetS. Among the MetS patients, 35.1% had a body mass index (BMI) ≥25, 27.7% had hypertension, 10.8% had hyperglycemia, and 31.2% had dyslipidemia. Kidney stone morbidity was 14.5% in the MetS group and 7.9% in the non-MetS group (P<0.05). As the number of MetS characteristics increased, kidney stone morbidity showed a linear increasing trend (P<0.05 for trend). With an increase in BMI and blood triglycerides (TG), and a decrease in lipoprotein cholesterol (HDL-C), the incidence of kidney stones had an increasing trend (P<0.05 for trend). Sex, age and MetS were independent risk factors for the occurrence of kidney stones, with and odds ratio (OR) of 1.493 [95% confidence interval (CI): 1.264-1.763] for MetS. Of the MetS characteristics, BMI ≥25 and blood pressure (BP) ≥140/90 mmHg were independent risk factors for kidney stones, with OR values of 1.209 (95% CI: 1.047-1.396) and 1.248 (95% CI: 1.071-1.453), respectively.
CONCLUSIONS
MetS is an independent risk factor for kidney stones. Appropriate medication and dietary advice may help to correct urinary metabolic abnormalities and prevent the recurrence of kidney stones.
背景
研究健康筛查人群中代谢综合征（MetS）和肾结石的发病率，并探讨两者之间的相关性。
方法
分析2019年8月至2020年7月在苏州大学第一附属医院接受筛查的11827人的体检数据。MetS诊断标准基于中国糖尿病学会（CDS）2004年指南。采用多因素logistic回归分析MetS与各种特征及肾结石之间的相关性。趋势分析用P值表示，P<0.05表示差异有统计学意义。
结果
本研究包括6570名男性（55.6%，年龄46.15±13.653岁）和5257名女性（44.4%，年龄41.41±11.712岁）。其中，1036人（8.8%）患有肾结石，1552人（13.1%）患有MetS。在MetS患者中，35.1%的体重指数（BMI）≥25，27.7%患有高血压，10.8%患有高血糖，31.2%患有血脂异常。MetS组肾结石发病率为14.5%，非MetS组为7.9%（P<0.05）。随着MetS特征数量的增加，肾结石发病率呈线性上升趋势（趋势P<0.05）。随着BMI和血甘油三酯（TG）升高以及脂蛋白胆固醇（HDL-C）降低，肾结石发病率呈上升趋势（趋势P<0.05）。性别、年龄和MetS是肾结石发生的独立危险因素，MetS的比值比（OR）为1.493[95%置信区间（CI）：1.264-1.763]。在MetS特征中，BMI≥25和血压（BP）≥140/90 mmHg是肾结石的独立危险因素，OR值分别为1.209（95%CI：1.047-1.396）和1.248（95%CI：1.071-1.453）。
结论
MetS是肾结石的独立危险因素。适当的药物治疗和饮食建议可能有助于纠正尿液代谢异常，预防肾结石复发。
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