Krzych Łukasz J, Łój Piotr, Nowak Teresa, Kazura Wojciech, Knapik Piotr
Department of Anaesthesiology and Intensive Care, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.
Students' Scientific Society, Department of Anaesthesiology and Intensive Care, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.
Acta Biochim Pol. 2017;64(3):499-501. doi: 10.18388/abp.2017_1505. Epub 2017 Jun 24.
Many studies have suggested a link between long-term PPI treatment and hypomagnesaemia, though none of them investigated the short-term exposure in high-risk patients. We sought to investigate this issue in 90 critically ill patients. We assessed serum Mg concentrations, necessity of Mg supplementation, PPI dose, duration of PPI therapy and route of administration. In multiple analysis we found that Mg supplementation (positive effect/p=0.03) and enteral route of PPI administration (negative effect/p=0.02) had significant impact on Mg concentration. Although the deleterious relationship between short-term PPI treatment and Mg concentration was found, further studies should be provided to confirm this interesting effect.
许多研究表明长期使用质子泵抑制剂（PPI）治疗与低镁血症之间存在关联，不过这些研究均未调查高危患者的短期暴露情况。我们试图在90例危重症患者中研究这一问题。我们评估了血清镁浓度、补充镁的必要性、PPI剂量、PPI治疗持续时间及给药途径。在多因素分析中，我们发现补充镁（正向作用/p=0.03）及PPI肠内给药途径（负向作用/p=0.02）对镁浓度有显著影响。尽管发现了短期PPI治疗与镁浓度之间的有害关系，但仍需进一步研究来证实这一有趣的效应。
