Doornebal Joan, Bijlsma Rina, Brouwer René M L
Medisch Spectrum Twente, afd. Interne Geneeskunde, Enschede, The Netherlands.
Ned Tijdschr Geneeskd. 2009;153:A711.
Long-term use of proton pump inhibitors can lead to serious hypomagnesaemia. Intestinal magnesium absorption takes place by passive paracellular and active transcellular transport. It has been hypothesized that proton pump inhibitors impair the active transcellular magnesium transport. The resulting hypomagnesaemia may cause hypoparathyroidism, hypocalcaemia and hypokalaemia. Proton pump inhibitor-induced hypomagnesaemia is reversible: it resolves when proton pump inhibitors are stopped. The indication for long-term proton pump inhibitor treatment should be evaluated periodically.
长期使用质子泵抑制剂可导致严重低镁血症。肠道镁吸收通过被动的细胞旁转运和主动的跨细胞转运进行。据推测，质子泵抑制剂会损害主动跨细胞镁转运。由此产生的低镁血症可能导致甲状旁腺功能减退、低钙血症和低钾血症。质子泵抑制剂引起的低镁血症是可逆的：停用质子泵抑制剂后可缓解。应定期评估长期使用质子泵抑制剂治疗的指征。
