Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachsuetts Avenue, Cambridge, MA, 02139, USA.
Department of Chemical and Biomolecular Engineering, North Carolina State University, 911 Partners Way, Raleigh, NC, 27695, USA.
Angew Chem Int Ed Engl. 2017 Aug 7;56(33):9847-9850. doi: 10.1002/anie.201705148. Epub 2017 Jul 17.
We present an automated microfluidic platform for in-flow studies of visible-light photoredox catalysis in liquid or gas-liquid reactions at the 15 μL scale. An oscillatory flow strategy enables a flexible residence time while preserving the mixing and heat transfer advantages of flow systems. The adjustable photon flux made possible with the platform is characterized using actinometry. Case studies of oxidative hydroxylation of phenylboronic acids and dimerization of thiophenol demonstrate the capabilities and advantages of the system. Reaction conditions identified through droplet screening translate directly to continuous synthesis with minor platform modifications.
我们提出了一种自动化微流控平台，用于在 15 μL 规模下在液体或气液反应中进行可见光光氧化还原催化的流动研究。振荡流策略可实现灵活的停留时间，同时保留流动系统的混合和传热优势。该平台实现的可调光子通量通过光化学法进行了表征。苯硼酸的氧化羟化和巯基苯酚的二聚化的案例研究证明了该系统的功能和优势。通过液滴筛选确定的反应条件可通过少量平台修改直接转化为连续合成。
