Tang H L, Li J, Han J, Xu J, Mao Y R
National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2017 May 10;38(5):656-660. doi: 10.3760/cma.j.issn.0254-6450.2017.05.020.
To analyze the survival time of newly diagnosed HIV/AIDS cases and related factors in China in 2010. The reporting cards and follow-up cards of HIV/AIDS cases reported as of 31 December 2015 were collected from national AIDS information system. The newly diagnosed HIV/AIDS cases in 2010 were selected. The information of follow-up intervention, CD(4+)T cells (CD(4)) testing, antiretroviral treatment and mortality of the cases from 2010 to 2015 were analyzed. Life table method was applied to calculate the survival probability. Kaplan-Meier was used to draw survival curve and Cox proportion hazard regression model were used to identify the factors related to survival time. Of the 40 335 HIV/AIDS cases, 11 975(29.7) died of AIDS related diseases. The median survival time was 63.1 months (95: 63.0-63.2), and the survival rates in 1 year and 5 years were 81.2 and 69.9. Multivariate Cox regression analysis showed that the risk factors for death in the HIV/AIDS cases were age (25-34 years old 15-24 years old: =1.41, 95: 1.29-1.54; 35-34 years old 15-24 years old: =1.90, 95: 1.74-2.07; 45-54 years old 15-24 years old: =2.24, 95: 2.04-2.46; ≥55 years old 15-24 years old: =2.81, 95: 2.57-3.08). The protective factors for death in the HIV/AIDS cases were level of baseline CD(4) counts (CD(4)≥500 cells/μl CD(4)<200 cells/μl: =0.12, 95: 0.11-0.13), receiving antiretroviral therapy (ART no ART: =0.11,95: 0.10-0.12). Survival time of HIV/AIDS cases might be influenced by age, baseline CD(4) count and access to antiretroviral therapy. The early diagnosed and early antiretroviral therapy could extend the survival time of HIV/AIDS cases.
分析2010年中国新诊断的艾滋病病毒/艾滋病(HIV/AIDS)病例的生存时间及相关因素。从国家艾滋病信息系统收集截至2015年12月31日报告的HIV/AIDS病例报告卡和随访卡。选取2010年新诊断的HIV/AIDS病例。分析这些病例2010年至2015年的随访干预、CD(4+)T细胞(CD(4))检测、抗逆转录病毒治疗及死亡情况。应用寿命表法计算生存概率。采用Kaplan-Meier法绘制生存曲线,Cox比例风险回归模型用于识别与生存时间相关的因素。在40335例HIV/AIDS病例中,11975例(29.7%)死于艾滋病相关疾病。中位生存时间为63.1个月(95%置信区间:63.0 - 63.2),1年和5年生存率分别为81.2%和69.9%。多因素Cox回归分析显示,HIV/AIDS病例死亡的危险因素为年龄(25 - 34岁比15 - 24岁:风险比=1.41,95%置信区间:1.29 - 1.54;35 - 44岁比15 - 24岁:风险比=1.90,95%置信区间:1.74 - 2.07;45 - 54岁比15 - 24岁:风险比=2.24,95%置信区间:2.04 - 2.46;≥55岁比15 - 24岁:风险比=2.81,95%置信区间:2.57 - 3.08)。HIV/AIDS病例死亡的保护因素为基线CD(4)计数水平(CD(4)≥500个细胞/μl比CD(4)<200个细胞/μl:风险比=0.12,95%置信区间:0.11 - 0.13)、接受抗逆转录病毒治疗(ART组比未接受ART组:风险比=0.11,95%置信区间:0.10 - 0.12)。HIV/AIDS病例的生存时间可能受年龄、基线CD(4)计数及抗逆转录病毒治疗可及性的影响。早期诊断及早期抗逆转录病毒治疗可延长HIV/AIDS病例的生存时间。