Cooke E D, Bowcock S A, Smith A T
Eur J Clin Pharmacol. 1985;29(1):33-6. doi: 10.1007/BF00547365.
The presence of cold sensitivity was investigated in three groups of patients; untreated hypertensives and hypertensives treated by a beta-adrenoceptor blocker (propranolol) or by a combined alpha- and beta-adrenoceptor blocker (labetalol) at two ambient temperatures. At a comfortable ambient (24 degrees C) one-third of the untreated and those treated with beta-blockade only showed cold sensitivity as compared with 16% of patients on the combined therapy. Under conditions of mild cold stress (20 degrees C) cold sensitivity increased in frequency in all three groups, more than half of the untreated and beta-blocked patients were affected and greater than one-third of those with alpha- and beta-blockade. These findings indicate that in the general population of hypertensives treatment with beta-adrenoceptor blockade alone may have little effect on the peripheral vasculature and that a useful degree of protection may be provided by therapy which blocks both receptors.
研究了三组患者的冷敏感情况；未治疗的高血压患者以及分别接受β-肾上腺素能受体阻滞剂（普萘洛尔）或α-和β-肾上腺素能受体联合阻滞剂（拉贝洛尔）治疗的高血压患者，研究在两个环境温度下进行。在舒适的环境温度（24摄氏度）下，未治疗组和仅接受β-阻滞剂治疗组中有三分之一表现出冷敏感，而联合治疗组中这一比例为16%。在轻度冷应激条件下（20摄氏度），三组患者的冷敏感发生率均增加，未治疗组和接受β-阻滞剂治疗组中超过一半的患者受到影响，而接受α-和β-阻滞剂联合治疗组中超过三分之一的患者受到影响。这些发现表明，在高血压患者的总体人群中，单独使用β-肾上腺素能受体阻滞剂治疗可能对外周血管系统影响不大，而同时阻断两种受体的治疗可能会提供有效的保护程度。
