拉贝洛尔与普萘洛尔治疗高血压的比较。
Comparison of labetalol and propranolol in hypertension.
作者信息
Nicholls D P, Husaini M H, Bulpitt C J, Stephens M D, Butler A G
出版信息
Br J Clin Pharmacol. 1980 Mar;9(3):233-7. doi: 10.1111/j.1365-2125.1980.tb04832.x.
Abstract
1 Labetalol has been compared with propranolol in a double-blind, double-dummy study of 24 patients with mild or moderate essential hypertension. 2 Two patients were unable to tolerate propranolol and five labetalol, because of symptom side effects; this difference was not significant (P greater than 0.1). 3 On a self-administered questionnaire, labetalol was associated with a greater number of side effects per patient than propranolol, but no individual side effect was significantly more common with either drug. 4 There was no difference in the number of spontaneously reported side effects between the two drugs. 5 Both drugs impaired pulmonary function, but propranolol caused a greater reduction than labetalol after 8 weeks of treatment. 6 We conclude that labetalol and propranolol are similarly effective and acceptable to the patient.
摘要
- 在一项针对24例轻度或中度原发性高血压患者的双盲、双模拟研究中，对拉贝洛尔和普萘洛尔进行了比较。2. 由于出现症状性副作用，有2例患者无法耐受普萘洛尔，5例患者无法耐受拉贝洛尔；这种差异不显著（P大于0.1）。3. 根据一份自行填写的问卷，与普萘洛尔相比，拉贝洛尔每位患者出现的副作用更多，但两种药物的任何一种单独副作用都没有明显更常见。4. 两种药物自发报告的副作用数量没有差异。5. 两种药物均损害肺功能，但治疗8周后，普萘洛尔导致的肺功能下降比拉贝洛尔更明显。6. 我们得出结论，拉贝洛尔和普萘洛尔在疗效上相似，患者对它们的接受程度也相似。
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Haemodynamic adaptation at rest and during exercise to long-term antihypertensive treatment with combination of beta-receptor blocking and vasodilator agent.静息及运动时血流动力学对β受体阻滞剂与血管扩张剂联合长期降压治疗的适应性
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Comparative anti-hypertensive effects of labetalol and the combination of oxprenolol and phentolamine.拉贝洛尔与氧烯洛尔和酚妥拉明联合用药的抗高血压效果比较
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