Claeson Anna-Sara, Gouveia-Figueira Sandra, Häggström Jenny, Fowler Christopher J, Nording Malin L
Department of Psychology, Umeå University, Sweden.
Department of Chemistry, Umeå University, Sweden.
Prostaglandins Leukot Essent Fatty Acids. 2017 Jun;121:60-67. doi: 10.1016/j.plefa.2017.06.004. Epub 2017 Jun 15.
Oxylipins and endocannabinoids play important biological roles, including effects upon inflammation. It is not known whether the circulating levels of these lipids are affected by inhalation of the environmental pollutant acrolein. In the present study, we have investigated the consequences of low-level exposure to acrolein on oxylipin, endocannabinoid and related lipid levels in the plasma of healthy individuals and individuals with chemical intolerance (CI), an affliction with a suggested inflammatory origin. Participants were exposed twice (60min) to heptane and a mixture of heptane and acrolein. Blood samples were collected before exposure, after and 24h post-exposure. There were no overt effects of acrolein exposure on the oxylipin lipidome or endocannibinoids detectable in the bloodstream at the time points investigated. No relationship between basal levels or levels after exposure to acrolein and CI could be identified. This implicates a minor role of inflammatory mediators on the systemic level in CI.
氧化脂质和内源性大麻素发挥着重要的生物学作用，包括对炎症的影响。目前尚不清楚这些脂质的循环水平是否会受到环境污染物丙烯醛吸入的影响。在本研究中，我们调查了低水平接触丙烯醛对健康个体以及患有化学不耐受（CI）个体（一种被认为具有炎症起源的疾病）血浆中氧化脂质、内源性大麻素及相关脂质水平的影响。参与者分别两次（每次60分钟）接触庚烷以及庚烷和丙烯醛的混合物。在接触前、接触后以及接触后24小时采集血样。在所研究的时间点，丙烯醛暴露对血液中可检测到的氧化脂质组或内源性大麻素没有明显影响。未发现接触丙烯醛前的基础水平或接触后的水平与化学不耐受之间存在关联。这表明炎症介质在化学不耐受的全身水平上作用较小。
