单次最大运动量锻炼可改善囊性纤维化患者的肺功能。
A single bout of maximal exercise improves lung function in patients with cystic fibrosis.
机构信息
Georgia Prevention Institute, Augusta University, Augusta, Georgia, United States.
Georgia Prevention Institute, Augusta University, Augusta, Georgia, United States; Pediatric Pulmonology, Augusta University, Augusta, Georgia, United States.
出版信息
J Cyst Fibros. 2017 Nov;16(6):752-758. doi: 10.1016/j.jcf.2017.05.011. Epub 2017 Jun 23.
BACKGROUND
Responses to a single bout of exercise may provide critical information for maximizing improvements in pulmonary function following exercise training in cystic fibrosis (CF). We sought to determine if acute maximal exercise improves pulmonary function in patients with CF.
METHODS
Thirty-three patients with CF completed a comprehensive assessment of pulmonary function to determine forced vital capacity (FVC), forced expiratory volume in one second (FEV), and lung clearance index (LCI) prior to and immediately following maximal aerobic exercise on a cycle ergometer.
RESULTS
Following exercise, FVC (∆0.08±0.14L) and FEV (∆0.06±0.15L) increased, while LCI decreased (∆-0.71±0.93) (all p<0.05). Changes in FEV (%predicted) were associated with peak work (r=0.40, p=0.02) and peak pulmonary ventilation (r=0.45, p=0.01).
CONCLUSIONS
A single bout of maximal exercise acutely improves pulmonary function in patients with CF and improvements may be related to peak work and peak pulmonary ventilation.
背景
单次运动反应可能为运动训练后改善囊性纤维化（CF）患者的肺功能提供关键信息。我们旨在确定急性最大运动是否能改善 CF 患者的肺功能。
方法
33 例 CF 患者在最大有氧自行车运动前后完成了肺功能综合评估，以确定用力肺活量（FVC）、一秒用力呼气量（FEV）和肺清除指数（LCI）。
结果
运动后 FVC（增加 0.08±0.14L）和 FEV（增加 0.06±0.15L），而 LCI 降低（减少-0.71±0.93）（均 p<0.05）。FEV（%预测值）的变化与峰值做功（r=0.40，p=0.02）和峰值肺通气（r=0.45，p=0.01）相关。
结论
单次最大运动可急性改善 CF 患者的肺功能，改善可能与峰值做功和峰值肺通气有关。
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