Department of General Surgery, The First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University, 188 Shizi St, Suzhou, Jiangsu 215006, PR China; Department of General Surgery, The Affiliated Hospital of Yangzhou University, Yangzhou University, 365 Hanjiang Middle Road, Yangzhou, Jiangsu 225000, PR China.
Department of General Surgery, The First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University, 188 Shizi St, Suzhou, Jiangsu 215006, PR China.
J Control Release. 2017 Sep 10;261:318-336. doi: 10.1016/j.jconrel.2017.06.020. Epub 2017 Jun 23.
Adhesion is one of the most common postsurgical complications, occurring simultaneously as the damaged tissue heals. Accompanied by symptoms such as inflammation, pain and even dyskinesia in particular circumstances, tissue adhesion has substantially compromised the quality of life of patients. Instead of passive treatment, which involves high cost and prolonged hospital stay, active intervention to prevent the adhesion from happening has been accepted as the optimized strategy against this complication. Herein, this paper will cover not only the mechanism of adhesion forming, but also the biomaterials and medicines used in its prevention. Apart from acting as a direct barrier, biomaterials also show promising anti-adhesive bioactivity though their intrinsic physical and chemical are still not completely unveiled. Considering the diversity of human tissue organization, it is imperative that various biomaterials in combination with specific medicine could be tuned to fit the microenvironment of targeted tissues. With the illustration of different adhesion mechanism and solutions, we hope this review can become a beacon and further inspires the development of anti-adhesion biomedicines.
粘连是最常见的术后并发症之一，在受损组织愈合的同时发生。在某些情况下，粘连会伴随炎症、疼痛甚至运动障碍等症状，极大地降低了患者的生活质量。与高成本和长时间住院的被动治疗相比，积极干预以防止粘连发生已被认为是对抗这种并发症的优化策略。本文不仅涵盖了粘连形成的机制，还介绍了用于预防粘连的生物材料和药物。生物材料不仅可以作为直接屏障，还通过其内在的物理和化学性质显示出有前途的抗粘连生物活性，尽管这些性质尚未完全揭示。考虑到人体组织的多样性，各种生物材料与特定药物相结合以适应靶向组织的微环境是至关重要的。通过不同粘连机制和解决方案的说明，我们希望这篇综述可以成为一个灯塔，并进一步激发抗粘连生物医学的发展。
