Gao Yuan, Guo Junchang, Li Shuangyang, Ye Liansong, Lu Binyang, Liu Jiaxin, Luo Jing, Zhu Yijia, Chen Liuxiang, Peng Tingfa, Yang Jinlong, Wang Dehui, Xie Chaoming, Deng Xu, Hu Bing
Department of Gastroenterology and Hepatology, Digestive Endoscopy Medical Engineering Research Laboratory, West China Hospital, Med-X Center for Materials, Sichuan University, Chengdu, 610064, P. R. China.
Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu, 610054, P. R. China.
Adv Sci (Weinh). 2025 May;12(18):e2500138. doi: 10.1002/advs.202500138. Epub 2025 Mar 20.
Wound postoperative infection and adhesion are prevalent clinical conditions resulting from surgical trauma. However, integrating intraoperative repair and postoperative management into a dressing suitable for wounds with unpredictable surface shapes and surroundings remains a formidable challenge. Here, we attempt to introduce a dynamic antifouling surface as wound protective covering and report an in situ formation of slippery-adhesive Janus gel (SAJG) by assembling hydrogel (N-hydrosuccinimide ester-activated powders) and elastomer (Silicon oil-infused polydimethylsiloxane). First powders can rapidly absorb interfacial water to gel and bond to tissue based on network entanglement, forming a tough adhesive hydrogel. Then precured organosilicon is applied to hydrogel and bonded together, forming a slippery elastomer. Due to the molecular polarity difference between hydrogel and elastomer, SAJG exhibits anisotropic surface behavior as evidenced by liquid repellency (hydrophilic vs. hydrophobic), and adhesion performance (bioadhesion vs. antiadhesion). Further, in vivo models are constructed and results demonstrated that the SAJG can effectively prevent bacterial infection to promote wound healing and avoid postoperative adhesion. Predictably, the morphologically adaptive SAJG with slippery and adhesive properties will have tremendous potential in addressing complex wound infections and postoperative complications.
伤口术后感染和粘连是手术创伤导致的常见临床病症。然而，将术中修复和术后管理整合到一种适用于表面形状和周围环境不可预测的伤口的敷料中，仍然是一项艰巨的挑战。在此，我们尝试引入一种动态防污表面作为伤口保护覆盖物，并报告通过组装水凝胶（N-羟基琥珀酰亚胺酯活化粉末）和弹性体（注入硅油的聚二甲基硅氧烷）原位形成的滑黏双面凝胶（SAJG）。首先，粉末可迅速吸收界面水形成凝胶，并基于网络缠结与组织结合，形成坚韧的黏附性水凝胶。然后将预固化的有机硅应用于水凝胶并结合在一起，形成光滑的弹性体。由于水凝胶和弹性体之间的分子极性差异，SAJG表现出各向异性的表面行为，如拒液性（亲水性与疏水性）和黏附性能（生物黏附与抗黏附）所示。此外，构建了体内模型，结果表明SAJG可有效预防细菌感染，促进伤口愈合并避免术后粘连。可以预见，具有光滑和黏附特性的形态适应性SAJG在解决复杂伤口感染和术后并发症方面将具有巨大潜力。
