Department of Trauma & Orthopaedic Surgery, Epsom & St. Helier￢ﾀﾙs Hospital, Carshalton, SM5 1AA, UK.
Department of Trauma & Orthopaedic Surgery, Epsom & St. Helier￢ﾀﾙs Hospital, Carshalton, SM5 1AA, UK.
J Infect Public Health. 2018 Jan-Feb;11(1):85-88. doi: 10.1016/j.jiph.2017.04.001. Epub 2017 Jun 23.
The incidence of Clostridium difficile associated diarrhoea (CDAD) is greater in elderly patients. Probiotics may have a beneficial effect in the prevention of CDAD. However, their effect in elderly orthopaedic patients has not been previously reported. Between April 2013 and April 2014, 105 patients admitted with femoral neck fractures, and who required 3days of antibiotics for infection of any cause, were prescribed the probiotic ACTIMEL until 3days after the last antibiotic dose. The incidence of CDAD was compared with historical controls (April 2011￢ﾀﾓApril 2012). There was no significant reduction in the incidence of CDAD in patients receiving probiotics (OR: 0.9; 95% CI 0.27￢ﾀﾓ2.91; p=0.8) and therefore we cannot recommend the use of ACTIMEL containing Lactobacillus casei, Lactobacillus bulgaricus, and Streptococcus thermophiles for this purpose in this patient group.
艰难梭菌相关性腹泻（CDAD）的发病率在老年患者中更高。益生菌可能对预防 CDAD 有有益作用。然而，它们在老年骨科患者中的作用尚未得到报道。在 2013 年 4 月至 2014 年 4 月期间，105 名因任何原因需要 3 天抗生素治疗的股骨颈骨折患者被开具了益生菌 ACTIMEL，直到最后一次抗生素剂量后 3 天。将 CDAD 的发生率与历史对照（2011 年 4 月至 2012 年 4 月）进行了比较。接受益生菌治疗的患者 CDAD 的发生率没有显著降低（OR：0.9；95%CI 0.27￢ﾀﾓ2.91；p=0.8），因此我们不能推荐在该患者群体中使用含有干酪乳杆菌、保加利亚乳杆菌和嗜热链球菌的 ACTIMEL 来达到这一目的。
