Barbosa Maria Lucianny Lima, Albano Mariana Oliveira, Martins Conceição da Silva, Warren Cirle Alcantara, Brito Gerly Anne de Castro
Morphology Department, Medical School, Federal University of Ceará, Fortaleza, Brazil.
Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA, United States.
Front Med (Lausanne). 2023 Aug 10;10:1219225. doi: 10.3389/fmed.2023.1219225. eCollection 2023.
infection (CDI) is the leading cause of healthcare-associated diarrhea. This infection can particularly affect older adults, the most susceptible to CDI. Currently, the standard therapeutic measure is antibiotic therapy, which in turn increases the risk of recurrence of the infection by its collateral damage to the patient's microbiota. Probiotics are live microorganisms capable of maintaining balance in the intestinal microbiota. This study aims to perform an integrative review of the protective benefit of probiotics in CDI and diarrhea associated with . The PubMed, Scopus, and Web of Science databases, the 10-year time cutoff, and the Prism Flow diagram were used for data collection. We observed no consensus among the studies; however, three of the seven evaluated studies demonstrated that the use of probiotics in older adults could contribute to reducing the incidence of hospital-onset CDI. We also found that the studies evaluated a wide variety of microorganisms, particularly , associated with beneficial effects. More research is needed to understand the successful use of probiotics in the prevention of CDI in hospitalized older adults receiving antibiotics.
艰难梭菌感染（CDI）是医疗保健相关腹泻的主要原因。这种感染尤其会影响老年人，他们是最易感染CDI的人群。目前，标准治疗措施是抗生素治疗，而这反过来又会因其对患者微生物群的附带损害而增加感染复发的风险。益生菌是能够维持肠道微生物群平衡的活微生物。本研究旨在对益生菌在CDI及与之相关的腹泻中的保护作用进行综合评价。使用PubMed、Scopus和科学网数据库、10年的时间截止范围以及Prism流程图进行数据收集。我们发现各项研究之间没有达成共识；然而，七项评估研究中的三项表明，在老年人中使用益生菌有助于降低医院获得性CDI的发生率。我们还发现，这些研究评估了各种各样的微生物，尤其是与有益效果相关的微生物。需要更多的研究来了解在接受抗生素治疗的住院老年人中成功使用益生菌预防CDI的情况。
