Na Sae Jung, Park Hye Lim, O Joo Hyun, Lee Sung Yong, Song Kyo Young, Kim Sung Hoon
Department of Radiology, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
In Vivo. 2017 Jul-Aug;31(4):749-753. doi: 10.21873/invivo.11126.
Epstein-Barr virus-associated gastric cancer (EBVaGC) is one of the four molecular subtypes of gastric cancer, as defined by the classification recently proposed by The Cancer Genome Atlas. We evaluated the correlation between EBV positivity and F-fluorodeoxyglucose (F-FDG) uptake by positron emission tomography/computed tomography (PET/CT) in patients with gastric cancer.
We retrospectively enrolled patients with gastric cancer who underwent pretreatment F-FDG PET/CT and subsequent surgical resection, and then were diagnosed with advanced gastric cancer (pathologic stage ≥T2 with any N stage). Maximum standardized uptake values (SUV) of gastric cancer were measured by pretreatment F-FDG PET/CT. EBV sequences were detected by in situ hybridization (ISH) techniques. We analyzed the correlation between EBV positivity, clinicopathologic features and metabolic activity of the primary tumor.
A total of 205 patients were included and 15 (7.3%) patients were identified as having EBV-positive gastric cancer. Age, gender, tumor location, and histological type showed no significant differences between EBV-positive and negative groups. EBV-positive cancer is significantly more frequent in the higher-metabolic-tumor group than in the lower one (p=0.032). The mean SUV of gastric cancers showed significant differences between EBV-positive and negative groups (9.9±4.2 vs. 7.0±4.8, p=0.026).
The infection status of EBV was significantly related to the F-FDG uptake of primary tumors in patients with advanced gastric cancer.
爱泼斯坦-巴尔病毒相关胃癌（EBVaGC）是胃癌的四种分子亚型之一，这是根据癌症基因组图谱最近提出的分类法确定的。我们评估了胃癌患者中EBV阳性与正电子发射断层扫描/计算机断层扫描（PET/CT）检测的氟脱氧葡萄糖（F-FDG）摄取之间的相关性。
我们回顾性纳入了接受预处理F-FDG PET/CT及随后手术切除且被诊断为进展期胃癌（病理分期≥T2，任何N分期）的胃癌患者。通过预处理F-FDG PET/CT测量胃癌的最大标准化摄取值（SUV）。采用原位杂交（ISH）技术检测EBV序列。我们分析了EBV阳性、临床病理特征与原发肿瘤代谢活性之间的相关性。
共纳入205例患者，其中15例（7.3%）被确定为EBV阳性胃癌患者。EBV阳性组和阴性组在年龄、性别、肿瘤位置和组织学类型方面无显著差异。高代谢肿瘤组中EBV阳性癌症的发生率显著高于低代谢肿瘤组（p = 0.032）。胃癌的平均SUV在EBV阳性组和阴性组之间存在显著差异（9.9±4.2 vs. 7.0±4.8，p = 0.026）。
EBV感染状态与进展期胃癌患者原发肿瘤的F-FDG摄取显著相关。
