Karaca Özden, Meier-Menches Samuel M, Casini Angela, Kühn Fritz E
Molecular Catalysis, Department of Chemistry, Catalysis Research Center, Technische Universität München, Lichtenbergstr. 4, 85747 Garching bei München, Germany.
Chem Commun (Camb). 2017 Jul 20;53(59):8249-8260. doi: 10.1039/c7cc03074f.
Organometallic compounds currently occupy an important place in the field of medicinal inorganic chemistry due to the unique chemical properties of metal coordination compounds. Particularly, metal compounds ligated by N-heterocyclic carbenes (NHC) have shown high potential for biomedical applications as antimicrobial and anticancer agents during the recent 15 years. Although further studies are necessary to validate the modes of action of this family of compounds, a number of biological targets have been identified, including DNA secondary structures. This perspective review aims at providing an overview of the most representative examples of metal NHC complexes reacting with nucleic acids via different binding modes. It is organized according to the type of DNA secondary structure targeted by metal NHCs, highlighting the possible advantages of biomedical applications, including therapy and imaging.
由于金属配位化合物具有独特的化学性质，有机金属化合物目前在药用无机化学领域占据重要地位。特别是，在最近15年里，由N-杂环卡宾（NHC）配位的金属化合物作为抗菌和抗癌剂在生物医学应用中显示出了很高的潜力。尽管还需要进一步研究来验证这类化合物的作用模式，但已经确定了一些生物靶点，包括DNA二级结构。这篇综述旨在概述金属NHC配合物通过不同结合模式与核酸反应的最具代表性的例子。它是根据金属NHC靶向的DNA二级结构类型进行组织的，突出了生物医学应用（包括治疗和成像）的可能优势。
