Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
J Fluoresc. 2017 Nov;27(6):1937-1941. doi: 10.1007/s10895-017-2133-z. Epub 2017 Jun 26.
Copper 8-hydroxyquinoline-2-carboxaldehyde-thiosemicarbazide (CuHQTS) and copper 8-hydroxyquinoline-2-carboxaldehyde-4,4-dimethyl-3-thiosemicarbazide (CuHQDMTS) are two copper thiosemicarbazone complexes with potent anticancer activity on cisplatin-resistant neuroblastoma cells. This study aimed to evaluate anti-prostate cancer activity of these two copper complexes in vitro. Both CuHQTS and CuHQDMTS inhibited proliferation of prostate cancer cells and showed cytotoxicity on prostate cancer cells carrying green fluorescent protein (GFP) by fluorescent microscopic imaging. The findings of this study demonstrated anti-prostate cancer activity of CuHQTS and CuHQDMTS and suggested that GFP-carrying prostate cancer cells might be used for testing anticancer activity of copper complexes by fluorescent microscopic imaging.
铜 8-羟基喹啉-2-醛缩硫代氨基脲（CuHQTS）和铜 8-羟基喹啉-2-醛-4,4-二甲基-3-缩硫代氨基脲（CuHQDMTS）是两种具有顺铂耐药神经母细胞瘤细胞强效抗癌活性的铜硫代半卡巴腙配合物。本研究旨在评估这两种铜配合物在体外的抗前列腺癌活性。CuHQTS 和 CuHQDMTS 均抑制前列腺癌细胞的增殖，并通过荧光显微镜成像显示对携带绿色荧光蛋白（GFP）的前列腺癌细胞的细胞毒性。本研究结果表明 CuHQTS 和 CuHQDMTS 具有抗前列腺癌活性，并提示携带 GFP 的前列腺癌细胞可用于通过荧光显微镜成像测试铜配合物的抗癌活性。
