Stolzberg Daniel, Wong Carmen, Butler Blake E, Lomber Stephen G
Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada.
Brain and Mind Institute, University of Western Ontario, London, Ontario, Canada.
J Comp Neurol. 2017 Oct 15;525(15):3190-3206. doi: 10.1002/cne.24271. Epub 2017 Jul 16.
Brain atlases play an important role in effectively communicating results from neuroimaging studies in a standardized coordinate system. Furthermore, brain atlases extend analysis of functional magnetic resonance imaging (MRI) data by delineating regions of interest over which to evaluate the extent of functional activation as well as measures of inter-regional connectivity. Here, we introduce a three-dimensional atlas of the cat cerebral cortex based on established cytoarchitectonic and electrophysiological findings. In total, 71 cerebral areas were mapped onto the gray matter (GM) of an averaged T1-weighted structural MRI acquired at 7 T from eight adult domestic cats. In addition, a nonlinear registration procedure was used to generate a common template brain as well as GM, white matter, and cerebral spinal fluid tissue probability maps to facilitate tissue segmentation as part of the standard preprocessing pipeline for MRI data analysis. The atlas and associated files can also be used for planning stereotaxic surgery and for didactic purposes.
脑图谱在以标准化坐标系有效传达神经影像学研究结果方面发挥着重要作用。此外，脑图谱通过描绘感兴趣区域来扩展对功能磁共振成像（MRI）数据的分析，在这些区域上评估功能激活的程度以及区域间连接的测量。在此，我们基于已确定的细胞结构和电生理发现，介绍一种猫脑皮质的三维图谱。总共71个脑区被映射到从8只成年家猫在7T下获取的平均T1加权结构MRI的灰质（GM）上。此外，使用非线性配准程序生成一个通用模板脑以及GM、白质和脑脊液组织概率图，以促进组织分割，作为MRI数据分析标准预处理流程的一部分。该图谱及相关文件还可用于立体定向手术规划和教学目的。
