Ou-Yang J, He B, Rong X, Bei C-H
Guangzhou Blood Center, Guangzhou, Guangdong, China.
The Key Medical Disciplines and Specialties Program of Guangzhou, Guangzhou, Guangdong, China.
Transfus Med. 2017 Dec;27(6):421-427. doi: 10.1111/tme.12436. Epub 2017 Jun 27.
The aim of this study was to evaluate the effectiveness of recruitment of inactive donors by telephone call and cell phone short message service (SMS), to assess the causes of donor self-deferral and to determine the appropriate sample size for a formal study BACKGROUND: Blood donor retention is essential for sustaining blood safety and sufficiency.
We conducted a single-centre open-label parallel randomised controlled trial in Guangzhou, China. A total of 1188 inactive donors with the last donation between 2009 and 2013 were enrolled and randomly assigned to two intervention groups (telephone call and SMS groups) and one control group without any intervention. Donors were followed up for 7 months; their responses including donation activities were analysed.
The re-donation rates among the three groups were statistically significantly different (P = 0.044), particularly between the phone call group and the control group (P = 0.017). Within the phone call group, the re-donation rate was positively associated with the frequency of prior donation (P = 0.026), and the age of the donors (P = 0.043). Medical issues, time constraints and group donation were the main causes of self-deferral. The appropriate sample size for each group for a formal study to detect difference between the phone call and SMS groups was estimated to be 1429 participants.
Our findings suggest that active interventions, especially phone call reminders, can increase blood donation. Further studies are required to compare the efficacy and effectiveness between phone call and SMS reminders using a larger sample size.
本研究旨在评估通过电话和手机短信服务（SMS）招募非活跃献血者的有效性，评估献血者自我延期的原因，并确定正式研究的合适样本量。背景：维持献血者留存对于保障血液安全和充足至关重要。
我们在中国广州开展了一项单中心开放标签平行随机对照试验。共纳入1188名在2009年至2013年间最后一次献血的非活跃献血者，并将其随机分为两个干预组（电话组和短信组）和一个无任何干预的对照组。对献血者进行了7个月的随访；分析了他们包括献血活动在内的反应。
三组之间的再次献血率在统计学上有显著差异（P = 0.044），尤其是电话组和对照组之间（P = 0.017）。在电话组中，再次献血率与既往献血频率（P = 0.026）和献血者年龄（P = 0.043）呈正相关。医疗问题、时间限制和团体献血是自我延期的主要原因。估计正式研究中每组用于检测电话组和短信组之间差异的合适样本量为1429名参与者。
我们的研究结果表明，积极干预，尤其是电话提醒，可以增加献血量。需要进一步研究以更大样本量比较电话提醒和短信提醒之间的疗效和效果。
