Picciotti Pasqualina M, Carfì Angelo, Anzivino Roberta, Paludetti Gaetano, Conti Guido, Brandi Vincenzo, Bernabei Roberto, Onder Graziano
Pasqualina M. Picciotti, Angelo Carfì, Roberta Anzivino, Gaetano Paludetti, Guido Conti, Vincenzo Brandi, Roberto Bernabei, and Graziano Onder, Department of Gerontology, Neurosciences, Head and Neck and Orthopedics, Catholic University of the Sacred Heart, Rome, Italy.
Am J Intellect Dev Disabil. 2017 Jul;122(4):333-341. doi: 10.1352/1944-7558-122.4.333.
Increased life expectancy in persons with Down syndrome (DS) is associated with premature age-related changes. The aim of this study was to assess auditory function in adults with DS and to evaluate the prevalence of hearing loss in this population. Audiometric tests were performed in 72 adults with DS (mean age 37.3±10.1 years, 51.4% females). Air conduction pure tone average (PTA) thresholds at frequencies 0.5-1-2-4 kHz were calculated to assess hearing function. Hearing loss was present if the PTA threshold was > 20 dB hearing level. Higher frequencies of 4 and 8 kHz were also assessed. Hearing loss was shown in 47 (65.3%) participants. The prevalence of hearing loss increased with age, ranging from 42.86% in the 20-29 years group to 90.91% in the 50-59 years group. High frequencies (4 and 8 kHz) were more often impaired than other frequencies used to measure PTA. Thus, the study concluded hearing loss is common in adults with DS and shows a pattern compatible with precocious aging of the hearing system. Auditory evaluation is strongly recommended in adults with DS.
唐氏综合征（DS）患者预期寿命的延长与过早出现的年龄相关变化有关。本研究的目的是评估成年DS患者的听觉功能，并评估该人群中听力损失的患病率。对72名成年DS患者（平均年龄37.3±10.1岁，女性占51.4%）进行了听力测试。计算0.5 - 1 - 2 - 4 kHz频率下的气导纯音平均（PTA）阈值以评估听力功能。如果PTA阈值> 20 dB听力级，则存在听力损失。还评估了4 kHz和8 kHz的高频。47名（65.3%）参与者存在听力损失。听力损失的患病率随年龄增加，从20 - 29岁组的42.86%到50 - 59岁组的90.91%不等。高频（4 kHz和8 kHz）比用于测量PTA的其他频率更常受损。因此，该研究得出结论，听力损失在成年DS患者中很常见，并且呈现出与听力系统过早老化相符的模式。强烈建议对成年DS患者进行听觉评估。
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