再生康复：干细胞疗法与活动依赖性刺激相结合
Regenerative Rehabilitation: Combining Stem Cell Therapies and Activity-Dependent Stimulation.
作者信息
Moritz Chet T, Ambrosio Fabrisia
机构信息
Departments of Rehabilitation Medicine, Physiology & Biophysics, Electrical Engineering (Dr. Moritz), UW Institute for Neuroengineering, Center for Sensorimotor Neural Engineering, University of Washington School of Medicine, Seattle; and Departments of Physical Medicine & Rehabilitation, Physical Therapy, Bioengineering, and Microbiology & Molecular Genetics (Dr. Ambrosio), McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pennsylvania.
出版信息
Pediatr Phys Ther. 2017 Jul;29 Suppl 3(Suppl 3 IV STEP 2016 CONFERENCE PROCEEDINGS):S10-S15. doi: 10.1097/PEP.0000000000000378.
The number of clinical trials in regenerative medicine is burgeoning, and stem cell/tissue engineering technologies hold the possibility of becoming the standard of care for a multitude of diseases and injuries. Advances in regenerative biology reveal novel molecular and cellular targets, with potential to optimize tissue healing and functional recovery, thereby refining rehabilitation clinical practice. The purpose of this review is to (1) highlight the potential for synergy between the fields of regenerative medicine and rehabilitation, a convergence of disciplines known as regenerative rehabilitation; (2) provide translational examples of regenerative rehabilitation within the context of neuromuscular injuries and diseases; and (3) offer recommendations for ways to leverage activity dependence via combined therapy and technology, with the goal of enhancing long-term recovery. The potential clinical benefits of regenerative rehabilitation will likely become a critical aspect in the standard of care for many neurological and musculoskeletal disorders.
再生医学领域的临床试验数量正在迅速增长，干细胞/组织工程技术有可能成为多种疾病和损伤的护理标准。再生生物学的进展揭示了新的分子和细胞靶点，有可能优化组织愈合和功能恢复，从而完善康复临床实践。本综述的目的是：（1）强调再生医学与康复领域之间协同作用的潜力，即再生康复这一学科融合领域；（2）提供神经肌肉损伤和疾病背景下再生康复的转化实例；（3）提出通过联合治疗和技术利用活动依赖性的方法建议，以增强长期恢复效果。再生康复的潜在临床益处可能会成为许多神经和肌肉骨骼疾病护理标准的关键方面。
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